Company Summary:

Flagship Labs 75, Inc. (FL75) is a privately held, early stage biotechnology company that is pioneering the development of multi-specific medicines to deliberately and systematically drug complex biology. FL75 is a highly dynamic, entrepreneurial and innovation-driven organization seeking to hire an exceptional protein engineer to join our team.

FL75 was founded in Flagship’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY) and Seres Therapeutics (NASDAQ: MCRB) were conceived and created. Since Flagship’s founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures resulting in over $34 billion in aggregate value, more than 500 issued patents and more than 50 clinical trials for novel therapeutic agents.

Position Summary:

Flagship Labs 75, Inc is looking for a highly motivated and enthusiastic Research Scientist to join our Protein Sciences team. This individual will be part of the team that is responsible for the design and expression of therapeutic bispecific antibodies and other cell-lines and protein reagents. This is an exciting opportunity to contribute to the development of the next generation of biologics in a highly collegial environment.

Key Responsibilities

  • Contribute to the design and production of monoclonal/bispecific antibodies and other biologics molecules of interest to the company
  • Clone/generate plasmid DNA constructs for expression of therapeutic and other proteins using standard and seamless cloning techniques
  • Perform biochemical and biophysical assessments of expressed proteins
  • Partner collaboratively and seamlessly with the in vivo and biological sciences teams to effectively investigate new candidate molecules.
  • Present results and conclusions and next steps clearly and succinctly to the team.
  • Support, mentor and grow direct reports (Research Associates).
  • Contribute effectively to patent filings.
  • Maintain clear, accurate written records of laboratory procedures, results and conclusions.

Required Qualifications:

  • PhD or equivalent in biochemistry, molecular or structural biology, or related disciplines with 2+ years of relevant experience in biotech/pharma.
  • Comprehensive background in protein structure/function with hands-on experience in antibody engineering/optimization and protein expression, purification and characterization, and expertise in assessing protein activity and drug developability.
  • Experience in the following:
    • Gene design, vector construction, and protein expression.
    • SDS-PAGE, HPLC, ELISA, Octet, SPR, flow cytometry/FACS
    • Structural modeling, epitope mapping, protein structure-function relationships
    • Cell culture and large-scale transient transfections for protein expression.
    • Protein purification techniques using a variety of methods.
  • Possession of strong communication skills, both written and verbal, to clearly convey results and scientific data to senior leaders, teams, academic collaborators and partners.
  • Experience in project leadership, driving strategy and timelines
  • Highly motivated strong team player who enjoys working in a fast-paced, inclusive, ethical, team-oriented, multidisciplinary environment of a small biotech.

Preferred Qualifications:

  • Experience with bispecific, and other non-traditional formats 
  • Mass spectrometry experience is a plus.
 

Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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