Company Summary:

Tessera Therapeutics is an early-stage life sciences company pioneering Gene Writing, a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy. Tessera Therapeutics was founded by Flagship Pioneering, a life sciences innovation enterprise that conceives, resources, and develops first-in-category companies to transform human health and sustainability.

Position Summary:

Tessera Therapeutics is seeking a motivated and creative Research Associate/Senior Research Associate to join a team of scientists and engineers focused on development of robust and scalable purification processes for manufacture of AAV viral vectors.

Key Responsibilities:

  • Assist with experimental design and execution of different downstream unit operations including chromatography and membrane separations (e.g, tangential flow filtration, depth filtration, sterile filtration).
  • Execute the experimental plan and interpret the results with minimal guidance.
  • Perform chromatography experiments using AKTA and high throughput (e.g., Tecan) systems.
  • Perform bench scale filtration experiments and assist with process scale-up.
  • Troubleshoot lab workflows and maintain lab equipment.
  • Provide high quality results and maintain high quality documentation in electronic lab notebooks.
  • Assist in development of in-house AAV production capabilities to supply of high quality AAV for pre-clinical and platform development.
  • Interact with external CMOs, vendors, and partners and assist in technology transfers to CMOs.
  • Collaborate effectively with purification and analytical development teams.
  • Draft protocols and technical reports and participate/present to stakeholders internally and externally.

Basic Qualifications:

  • BS/MS with 3+ years of relevant industrial experience. Degree emphasis in Chemical Engineering, Bioengineering, or Biological Sciences.
  • Strong technical understanding and experience with chromatography and membrane separations for viral vectors or biologics is required.  Prior experience with AAV purification development is strongly preferred.
  • Hands-on experience with AKTA chromatography and tangential flow filtration systems is required.
  • Experience with high-throughput purification process development is desirable.
  • Track record of planning experiments/projects and completing deliverables within specified timelines.
  • Involved in evaluation of novel technologies to improve the existing purification processes.
  • Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner.
  • Experience with cell culture and analytical assays is desirable.
  • A strong self-starter with excellent organizational skills and a strong attention to details.
  • Eager to work with highly skilled and dynamic teams in a fast-paced, entrepreneurial, and technical setting.
  • Proficient in MS Office.


More About Flagship Pioneering

Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has, through its Flagship Labs unit, applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $50B in aggregate value. To date, Flagship has deployed over $2.2B in capital toward the founding and growth of its pioneering companies alongside more than $18B of follow-on investments from other institutions. The current Flagship ecosystem comprises 41 transformative companies, including Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Foghorn Therapeutics (NASDAQ: FHTX), Indigo Ag, Kaleido Biosciences (NASDAQ: KLDO), Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology, Seres Therapeutics (NASDAQ: MCRB), and Sigilon Therapeutics (NASDAQ: SGTX).

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies:  Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates.  The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team.   Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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