Generate Biomedicines, Inc. is a Flagship backed, privately-held biotechnology company on a mission to reimagine the drug discovery process to one of dynamic, data-driven generation. We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. Generate will be successful by constantly turning innovative ideas into methods, technologies, and products that solve some of the most difficult challenges with developing medicines. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!
Generate was founded by Flagship Pioneering. Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $34 billion in aggregate value. The current Flagship ecosystem comprises 41 transformative companies, including: Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Foghorn Therapeutics, Indigo Ag, Kaleido Biosciences (NASDAQ: KLDO), Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology, Seres Therapeutics (NASDAQ: MCRB), and Syros Pharmaceuticals (NASDAQ: SYRS).
Generate Biomedicines is looking for an individual to be a part of a growing protein sciences department that is leveraging automated high-throughput platforms in multiple areas of molecular biology through protein production and characterization. The individual will contribute to workflows that include cloning, DNA scale-up and purification, protein expression and purification, assessment of protein-protein interactions, and biophysical characterization for a variety of protein modalities. They will work collaboratively with the team in developing, optimizing, and executing state-of-the-art high-throughput methods for cloning, DNA purification, protein expression, protein purification and characterization methods (eg: HPLC-based). They will operate automated liquid handling robots, design experiments, optimize throughput, maintain detailed records, and generate standard operating procedures. This is an exciting opportunity to be part of a fast-paced, start-up environment!
Responsibilities may include, but are not limited to:
- Scale up protocols and adapt them for automation on liquid handling robots.
- Contribute to development of high-throughput automated protein expression and purification workflows.
- Protein quality control methodologies to assess purity, stability, non-specific binding, etc., employing a variety of analytical equipment.
- Data presentation and documentation; writing SOPs
- Practical experience with:
- Operation of liquid handling robots
- Basic to advanced understanding of scripting and computer logic
- Molecular cloning, DNA scale-up and purification
- Small-scale HTP Protein production methodologies
- Analytical chromatographic separation techniques (eg: analytical SEC)
- SDS-PAGE, Western blots
- Deep understanding of:
- Transient HEK and CHO cell transfection techniques
- Protein characterization
- Excellent attention to detail, documentation, and communication skills
Minimum Education Experience: B.S
Minimum Industry Experience: 2-3 years in Biotech/Pharma
Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.