Ring Therapeutics Inc. is a privately held, early-stage biotechnology company pioneering a completely novel form of gene therapy by exploiting a family of naturally occurring commensal viruses to create the first redosable and targetable DNA medicines. This approach enables a powerful new class of tropic, persistent, non-integrating vectors that overcome the immunogenicity, and limited tropism of existing gene therapy vectors. Ring Therapeutics is leveraging this versatile technology to develop a broad pipeline of novel, targeted medicines for disease with high unmet medical need.
Ring Therapeutics was founded by Flagship Pioneering, focused on launching breakthrough companies based on internally conceived innovations and insights. Flagship Pioneering has created over 40 groundbreaking companies over the past fifteen years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Seres Therapeutics (NASDAQ:MCRB), Moderna (MRNA), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Axcella Health (AXLA), Evelo Biosciences (EVLO), and Indigo Agriculture.
Ring Therapeutics is seeking a viral vector and translational scientist to join the Translation team to help develop new DNA medicine technologies. The candidate will help characterize novel viral genomes, capsids, and different therapeutic payloads to support the development of the gene therapy platform. The candidate will help characterize and optimize engineered viral vectors. The candidate will design experiments, perform experiments, analyze, and present data. This will be a great opportunity to participate in cutting-edge virology, viral genome engineering, and translational biology research. We are searching for enthusiastic and highly motivated individuals who are comfortable multitasking and working both with a team and independently on various aspects of the viral platform development.
- Characterize novel viruses
- Design and test engineered viral capsids, genomes, and therapeutic payloads
- Develop novel gene therapy vectors
- In vitro and in vivo characterization of the novel developed vectors
- Supervise research associates supporting key research objectives
- Maintain lab notebooks, and report results to the scientific team
- Ph.D. in virology or closely related field.
- 2 years of postdoctoral experience, in academic, pharmaceutical, or biotechnology settings.
- Experience with
- design and characterization of viral vectors, particularly for gene therapy applications
- classical virology techniques including virus culture, isolation (e.g., via centrifugation methods, including isopycnic), and quantification (infectivity, transduction assays, plaque assays, TCID, etc…)
- molecular biology and recombinant DNA techniques, including transfections of mammalian cells.
- Design and execution of assays to measure the expression and activity of payloads such as RT-qPCR, ELISA, FACS, etc.
- Demonstrated ability to work with highly skilled teams in a fast-paced, entrepreneurial, and technical environment.
- Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner.
- Comfortable delivering against challenging commitments.
- Confident, execution focused, team oriented, with an ability to thrive in an entrepreneurial environment.