The Company:

Inzen Therapeutics is a privately held, early-stage biotechnology company exploring Thanocrine SignalingTM as a surprising and important driver of disease.  While communication between living cells is a well-established concept, Inzen has identified Thanocrine Signaling as a form of communication between dying and living cells. The way a cell dies matters, and we have found that this process plays an under-appreciated role in a variety of diseases.  Our mission is to pioneer a novel category of drugs based on manipulating Thanocrine SignalingTM for the treatment of cancer, immune and fibrotic diseases, and regenerative processes.

Inzen Therapeutics was founded by Flagship Pioneering, an organization dedicated to the origination and development of first-in-category life sciences companies.  Since 2000, Flagship has originated and fostered the development of nearly 100 scientific ventures resulting in $20+ billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. 

The Position:

Inzen Therapeutics offers the challenge and opportunity to work at an early stage, big concept biotechnology company.  We are seeking a Senior Scientist/Principal Scientist to join our Fibrosis & Regeneration group, which is focused on identifying and prosecuting new targets and first-in-class drug concepts to treat fibrotic diseases based on new insights into cellular turnover. 

The candidate will be an ambitious, accomplished scientist with a strong background in fibrotic disease to join the Fibrosis & Regeneration team as a Sr. Scientist/Principal Scientist, Tissue Fibrosis & Regeneration. In this position, the successful candidate will develop and execute the strategy to identify novel targets in fibrotic disease and rapidly transition to drug discovery programs. The ideal candidate will be exceptionally grounded in the fundamental biology of fibrotic disease across a range of indications including IPF, NASH, renal, pancreatic, systemic sclerosis, cardiac and/or myelofibrosis. S(h)e will have broad expertise on the use of in vitro, ex vivo and in vivo models of fibrosis to demonstrate therapeutic efficacy.  They will foster a collaborative team environment, champion innovative scientific concepts, execute experimental plans, and create data packages that will lead to novel drug concepts against these targets.

We are looking for an individual with a track record of accomplishments in developing and executing innovative assays and methodologies.  S(he) should be a skilled scientist and excellent communicator, innovative, and comfortable in a fast-paced, entrepreneurial environment.

Key Responsibilities:

  • Develop and execute the strategy/ies to identify and validate novel mechanisms driving fibrotic disease
  • Incorporate state-of-the-art in vitro, ex vivo and in vivo models to demonstrate efficacy and therapeutic potential of novel fibrotic mechanisms
  • Provide data driven assessment of target translatability from preclinic to clinic
  • Help lead strategy and planning of early-stage research programs, including identifying, evaluating, and championing new ideas and technologies
  • Lead and collaborate with other scientists and research associates
  • Lead external research relationships with academic and commercial partners.

Key Requirements:

  • PhD degree with up to 5 years’ industry experience or BS or MS degree with 10 years relevant industry experience in fibrotic disease drug discovery
  • Possesses detailed and expert knowledge of scientific principles and concepts in the pathophysiology of fibrotic disease
  • Extensive experience in identifying and validating novel drug targets in fibrotic disease
  • Strong background in in vitro, ex vivo, and in vivo models of fibrotic disease and their translatability to the clinic
  • Proven track record of translating ideas into defined experimental plans, early target validation and drug discovery execution
  • Strong analytical and problem-solving skills
  • Demonstrated leadership ability and experience working in a matrix environment a plus
  • Excellent communicator, with the ability to clearly convey complex messages to many audiences
  • Confident, execution-focused, team-oriented.

 

Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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