Company Summary:

Tessera Therapeutics is pioneering Gene Writing™—a new genome engineering technology that writes therapeutic messages into the genome to treat diseases at their source. Tessera Therapeutics was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 40 groundbreaking companies over the past fifteen years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Seres Therapeutics (NASDAQ:MCRB), Moderna (MRNA), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Axcella Health (AXLA), Evelo Biosciences (EVLO), and Indigo Agriculture.

 Position Summary:

Tessera Therapeutics is seeking a Scientist to develop lipid nanoparticle (LNP) formulation process and produce LNP-encapsulated RNAs and plasmids to support company’s in vitro and pre-clinical studies. In addition, the successful candidate will develop drug product characterization assays and characterize the produced LNP batches. The ideal candidate will be proactive, enthusiastic, and show a passion for process development. The applicant should have strong communication and collaboration skills, along with a strong background in formulation process development and in LNP characterization. 

Key Responsibilities:

  • Develop nanoparticle formulation process
  • Use DOE to evaluate formulation factors and parameters to optimize lead formulations
  • Formulate RNAs and plasmids to support company’s in vitro and pre-clinical studies
  • Develop analytical methods to characterize formulations
  • Develop and perform analytical testing supporting drug product process development and drug product characterization
  • Independently plan and execute experiments
  • Perform data analysis and trending
  • Deliver reproducible and impactful results under ambitious timelines
  • Understand the landscape of clinical and process materials, liaison with vendors, and maintain appropriate inventory
  • Maintain thorough electronic lab notebooks and documentation records
  • Adhere to all laboratory safety requirements and procedures, assist in maintaining general laboratory functionality, including lab equipment maintenance and the ordering and receiving of lab supplies
  • Create and write analytical reports and SOPs to support development and regulatory filings
  • Document all experimental planning and progress in electronic lab notebook, prepare PowerPoint slides and present your finding to multi-disciplinary teams


  • PhD with 0-2 years of experience in Chemistry, Analytical Chemistry, Chemical Engineering, Biochemistry, or related discipline
  • Experience with nanoparticle formulation process development and analytical characterization techniques such as DLS, fluorescence assays, HPLC
  • Knowledge of statistical design of experiments (DoE) and analysis is a plus
  • Knowledge of nucleic acid chemistry and biology is a plus
  • Knowledge of process scale up/scale down is a plus
  • Knowledge of GMP and GLP regulations
  • Preferred: Experience with nanoparticle formulations
  • Highly self-motivated, driven, can-do, make it happen attitude with ability to own and drive projects
  • Strong collaborator with cross-functional teams and external partners
  • Capable of continuous learning, open-minded, curious, highly organized and detail-oriented


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