Company Summary:

Generate Biomedicines is a privately-held biotechnology company that is pioneering Generative Biology to bring control and intentionality to the development of medicines. Generate has developed a proprietary, multi-product Generative Biology Engine to create potent biologics in multiple therapeutic modalities. Generate was founded by Flagship Pioneering in the Flagship Labs innovation foundry. Flagship Pioneering creates, resources, and builds life science companies that invent breakthrough technologies in order to transform healthcare and sustainability. Flagship has created over 100 groundbreaking companies since 2000, including Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Indigo Agriculture and Sana Biotechnology.

Position Summary:

Generate Biomedicines is seeking to expand the Research & Development team by recruiting a talented Senior Research Associate to play a leading role in the development of its Immunogenicity program, focused on  minimizing immunological detection, or immunogenicity, of our therapies through novel approaches. This is a unique opportunity to join our team at a critical early stage of its development where you will lead efforts to establish industry standard workflows while investigating novel biology and pioneering new methodologies in the immunogenicity space. While supporting broader team initiatives, you will be directly responsible for leading the design and execution of in vitro and in vivo assays to support company wide programs spanning various therapeutic modalities and diseases. You will be involved in the development and execution of immunogenicity assays utilizing cell lines and primary immune cell cultures (human and mouse), while actively collaborating with our Machine Learning, Computational Biology and Protein Sciences groups. You will be responsible for the design and execution of experiments, data analysis and interpretation, documentation, presentation of work in internal meetings and in written reports.  We are searching for an enthusiastic, innovative, well-organized, and self-motivated individual who is comfortable working in a fast-paced, entrepreneurial environment.

Key Responsibilities:

  • Source, plan and establish immunogenicity assays for the assessment of Generate’s protein-based therapeutics
  • Evaluate multiple assay formats to identify the most relevant assay for each project and modality
  • Generate hypotheses and design experimental plans to validate novel approaches to the assessment and mitigation of protein immunogenicity
  • Assist with establishment and expansion of internal wet lab capabilities and relationships with external CROs and collaborators to drive projects from ideation to functional validation
  • Collaborate closely with team members in the Machine Learning, Computational Biology and Protein Sciences functions in a matrix environment
  • Presentation of findings, conference/webinar attendance and summary of the novel learnings

Experience and Qualifications:

  • B.S. with 5-8+ years’ experience, M.S. with 3-6+ years’ experience, or Ph.D. with 0+ years’ experience in immunology, cell biology or a related field, industry experience preferred
  • Strong experience with mammalian cell culture techniques, including isolating, culturing, and assaying primary human and murine immune cells
  • Direct experience with performing T cell stimulation assays, B cell culture and Monocyte-derived DC induction a plus
  • Strong experience with immunological techniques including multi-parameter flow cytometry and/or cell sorting, immunoassays such as ELISA and ELISPOT, in vitroand primary cell based assays (MLR, PBMC cultures, etc.)
  • Familiarity with Graphpad Prism and FlowJo a plus
  • Demonstrated ability to develop, troubleshoot and execute experiments, analyze data, and report conclusions
  • Ability to parallel process multiple projects and modalities and support the growing portfolio
  • Able to thrive in a highly collaborative, fast-paced, team-oriented environment with colleagues from diverse disciplines
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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