Flagship Labs 63 Inc. (FL63) is a privately held, well-funded, early-stage platform biotechnology company that is leveraging emerging insights in RNA biology to develop novel human therapeutics with a focus on mRNA translation and post-transcriptional RNA modifications.

FL63 was founded by Flagship Pioneering, an innovation enterprise that conceives, resources and grows first-in-category life science companies. The firm’s institutional innovation foundry, Flagship Pioneering Labs, is where teams of scientific entrepreneurs systematically evolve ideas and turn previously undiscovered areas of science into real-world ventures. Flagship manages >$2.4B in funds and has applied its hypothesis-driven innovation process to foster 75 scientific enterprises. These companies represent >$19B in aggregate value, have been issued 500+ patents, and have conducted >50 clinical trials for novel therapeutic agents. Flagship’s portfolio companies include Moderna Therapeutics, Rubius Therapeutics, and Indigo Agriculture.

FL63 is a highly dynamic, entrepreneurial and innovation-driven organization seeking to hire an exceptional scientist to join our growing team. A successful candidate will have a B.S./M.S. in molecular biology/biotechnology (or equivalent), and an additional 7-10 years of pipeline NGS pipeline development & implementation experience. The candidate’s career goals, laboratory skills, and core competencies should be aligned with the description below.

Key Outcomes:

  1. Design, execute, and interpret multiple NGS experimental workflows with an emphasis on RNA-centric NGS.
  2. Continually cultivate scientific/technical expertise through critical review of the scientific literature, attending external conferences, and developing relationships with key opinion leaders.
  3. Work effectively with a cross-functional biology, technology, and chemistry team to contribute to the vision, strategy, and tactics of the organization.
  4. Willing to work hands-on in the wet lab for the first 1-3 years and to recruit/develop a team in 2-5 years.

Required Skills:

  1. Strong Illumina NGS background with a focus on RNA-seq, various RNA-centric NGS workflows (e.g. RNA-seq, Ribo-seq, eCLIP, RIP-seq, etc…), or equivalent methods/technologies (e.g. ChIP-seq).
  2. Deep experience in a wide range of standard NGS workflows including single cell RNA-seq, hybrid capture target enrichment, targeted RNA-seq (e.g. Amplicon-seq), and NGS library construction.
  3. Experience establishing NGS laboratory capacity/best practices & developing, improving, & deploying standard/novel NGS pipeline assays at scale in an industry/production environment.
  4. Proven track-record of scientific excellence as evidenced by both individual contributions and successful collaborations with molecular/computational biologists to generate hypothesis-generating data & scientific inferences resulting in elucidation of novel mechanisms.
  5. Solid all-round molecular (e.g. nucleic acid purification, PCR, RT-PCR, qPCR, enzymatic reactions, gel electrophoresis, etc…) & cell biology (mammaiian cell culture, Western blot, IF/ICC microscopy, etc…) toolkit enabling cross-functional contributions.

Preferred Skills:

  1. Exposure to Oxford Nanopore direct RNA sequencing technology and data analysis.
  2. Experience with lab automation/robotics & knowledge of modern statistics-based experimental design methods including Design of Experiments (DoE) models in JMP or equivalent.
  3. Working knowledge in the field of RNA biology.
  4. Experience in Life Science R&D cloud environments including Benchling & AWS.

Core Competencies:

  1. Fast-acting/efficient. Moves quickly and proactively with a strong work ethic to produce high-quality results while fostering a positive work environment. Focuses on key priorities. Demonstrates tenacity and willingness to go the distance to get something done.
  2. Integrity. Does not cut corners ethically. Earns trust and maintains confidences. Does what is right not just what is politically expedient. Speaks plainly and truthfully. Follows-through on commitments. Expects a high level of personal performance and team performance.
  3. Critical thinking and innovation. Learns quickly. Demonstrates ability to proficiently understand new information. Able to structure and process qualitative/quantitative data and draw insightful conclusions. Generates new and innovative approaches to problems.
  4. Teamwork. Reaches out to peers and cooperates with the team to establish an overall collaborative work environment. Often solicits and responds well to constructive feedback. Possesses good written and oral communication skills.
  5. Flexibility/adaptability. Adjusts quickly to changing strategic and tactical priorities.


Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto

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