Company Summary:

Tessera Therapeutics is pioneering Gene Writing to cure disease. Our genome is a mosaic comprising genes that protect us from, predispose us to, and cause disease. Gene Editing biotechnologies heralded the era of genome-modifying medicines, but they cannot address most diseases. Gene Writing is a new biotechnology that writes therapeutic messages into the genome to cure thousands of diseases at their source.

Tessera Therapeutics was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 40 groundbreaking companies over the past fifteen years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Seres Therapeutics (NASDAQ:MCRB), Moderna (MRNA), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Axcella Health (AXLA), Evelo Biosciences (EVLO), and Indigo Agriculture.

Position Summary:

The Scientist will be responsible for the engineering and directed evolution of therapeutic proteins. We are searching for a driven, enthusiastic and self-motivated individual who is comfortable multitasking and working independently on various aspects of the platform. This individual will join a dynamic, rapidly growing, and highly collaborative team.

Key Responsibilities:

The successful candidate will work both independently and as part of a collaborative team to:

  • Build, evaluate, and maintain DNA libraries
  • Creatively design, validate, and complete a directed evolution platform
  • Engineer and characterize gene editing proteins in vitro
  • Make detailed observations, analyze data and interpret results
  • Prepare technical reports, summaries, protocols, and quantitative analyses

Basic Qualifications:

  • Ph.D. in bioengineering, synthetic biology, or related field.
  • A proven track record of directed evolution or protein engineering expertise
  • Expertise with molecular biology, including advanced molecular cloning or mutagenesis techniques
  • Experience with DNA libraries and next-generation sequencing data sets
  • Excellent troubleshooting and capability, attention to detail and ability to work independently
  • Excellent communication and presentation skills
  • Confident, team oriented and self-motivated

Preferred Qualifications:

  • Experience with phage, yeast, or mammalian display
  • Bioinformatics and statistics skills, including experience with Python or Matlab
  • Experience in gene editing
  • Experience with mammalian cell culture


RECRUITING & STAFFING AGENCIES: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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