Flagship Labs 60 (FL60), the latest Flagship Pioneering company, has been founded through its venture creation engine, where companies such as Moderna Therapeutics, Rubius Therapeutics, and Evelo Therapeutics were conceived and created. Since Flagship’s founding in 2000, the firm has originated and fostered the development of nearly 100 scientific ventures resulting in $19+ billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. FL60 is integrating the latest developments in experimental biology to discover novel therapeutic strategies for a broad range of CNS disorders.
We are seeking a creative, collaborative, motivated scientist with diverse experiences and interests utilizing cutting-edge molecular and cellular biology tools for discovery research. The successful applicant will have a strong scientific background and proven accomplishments in the use of human pluripotent stem cells (hiPSCs/hESCs) and their derivatives to model CNS disorders for disease pathway and target discovery, target validation, and high-throughput screening to support drug discovery projects. The ideal candidate will be responsible for the generation, maintenance, differentiation and characterization of human pluripotent stem cells into various lineages for use in complex phenotypic and functional assays. Preference will be given to candidates with experience in identifying novel disease mechanisms in complex cell types. Extensive, hands-on cell line generation, cell differentiation optimization, and assay development are preferred. This is an exciting and interdisciplinary role for a highly qualified and motivated individual. S(he) will be comfortable working in and contributing to a very dynamic, cross-functional team environment with a passion for bringing novel medicines to patients.
- Lead Stem Cell Biology within Discovery Biology group
- Act as a critical interface between stem cell biology and assay development
- Act as a critical interface between stem cell biology and computational biology
- Contribute creatively and strategically to discussion and design of in vitro assays
- Establish robust, high-quality, scalable protocols for differentiation of human iPSCs into neuronal lineages, including utilizing 3 dimensional cultures
- Identify and implement innovative approaches to gain mechanistic insight into phenotypic assay results
- Manage stem cell biology workflow and data archiving using electronic laboratory management tools
- Manage relationships with external research facilities
- Report results to scientific team and management
- PhD in the biological sciences or related fields with 5+ years of relevant laboratory experience
- Extensive experience with pluripotent stem cell culture and differentiation
- Experienced in diverse molecular and cell biology techniques, including CRISPR gene editing, western blots, confocal microscopy, high content imaging, and flow cytometry
- Experience with a wide range of functional cell-based assays including but not limited to RNA-seq, single cell RNA-seq, proteomics, and electrophysiological analyses
- Demonstrated record of success with strong publication record
- Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner
- Strong neurobiology background
- Disease target discovery experience in the field of neuroscience
- Team oriented, highly motivated, execution focused with strong work ethic in an entrepreneurial environment
- Highly adaptable and responsive to technical and business opportunities and needs
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.