Company Summary:

Tessera Therapeutics is pioneering Gene Writing to cure disease. Our genome is a mosaic comprising genes that protect us from, predispose us to, and cause disease. Gene Editing biotechnologies heralded the era of genome-modifying medicines, but they cannot address most diseases. Gene Writing is a new biotechnology that writes therapeutic messages into the genome to cure thousands of diseases at their source.

Tessera Therapeutics was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 40 groundbreaking companies over the past fifteen years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Seres Therapeutics (NASDAQ:MCRB), Moderna (MRNA), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Axcella Health (AXLA), Evelo Biosciences (EVLO), and Indigo Agriculture.

Position Summary:

The successful candidate will bring passion, computational biology and bioinformatics expertise into a company pioneering a new type of genome engineering called Gene Writing. This person will be responsible enabling both the data-driven and data-centric activities that are at the core of advancing Tessera’s science.

Key Responsibilities:

  • Build and lead a 5+ person computational biology team, including recruiting and development of junior staff
  • Invent and oversee bioinformatic discovery using complex genomic data, including high throughput sequencing data from multiple platforms and databases
  • Develop computational methods and provide project support to Gene Writing project teams
  • Operationalize the data analysis aspects of molecular assays to maximize the design, build, test cycle for platform and pipeline candidates
  • Provide leadership by coordinating analysis activities across the organization
  • Create compelling data visualizations for internal and external presentations
  • Structure and store data to enable data reuse, data mining and machine learning
  • Facilitate collaboration with a machine learning team
  • Establish and oversee external analysis projects with collaborators and contract research organizations
  • Serve as part of the broader leadership team in setting goals, strategy, budgets, and evaluating project progress
  • Monitor and evaluate new and emerging analytical technologies, and identify opportunities for collaboration within Flagship Pioneering companies, academia, and third parties.

Basic Technical Qualifications:

  • Ph.D. in quantitative discipline or comparable experience: Bioinformatics, Statistics, Applied Mathematics, Computer Science, Biophysics, Computational Biology, Physics, Engineering or Machine Learning. Candidates with M.S. degree in above-named fields with extensive (at least 10 years) work experience will also be considered.
  • A proven computational biologist or bioinformatician with 8+ years of industry experience in discovery research or translational medicine
  • Experience analyzing gene therapy, gene editing, in vitro/vivo assay, genetics, genomics and cell biology data
  • Experience analyzing the multiple facets of next generation sequencing data, including amplicon sequencing, tag counting, exon sequencing
  • Experience using comparative genomics as a tool for gene discovery
  • Strong grounding in biology or medicine
  • Strong data visualization skills and experience
  • Fluency in one or more programming languages with bioinformatics applications (e.g. R/Bioconductor, Python, Perl).
  • Fluency with the full stack AWS environment

Basic Interpersonal Qualifications:

  • Experience building and managing a team of analysts and/or computational biologists
  • Experience navigating the “bi-lingual” nature of data analysis and science
  • Outstanding teamwork, communication and interpersonal skills
  • Proven contributions to cross-functional project teams
  • Ability to thrive in an entrepreneurial and multidisciplinary environment
  • The ability to effectively influence the work of others

Preferred Qualifications, if you have these it would be a plus:

  • Therapeutic expertise in oncology, immunologically-based or rare genetic diseases
  • Experience analyzing large scale oncology data
  • Experience with single cell sequencing data and/or other single cell technologies
  • Analysis experience with imaging and other profiling technologies
  • Experience analyzing high throughput screening data for drug or target discovery
  • Experience with other scripting tools or languages such as Matlab, Java and databases (e.g., MongoDB, MySQL)
  • Experience contributing scientific background and supporting data for patents and IND filings
RECRUITING & STAFFING AGENCIES: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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