Lead Security Engineer

POSITION LOCATION: San Francisco Bay Area, Remote candidates within the U.S. are strongly encouraged to
apply.

POSITION SUMMARY:

We are building a forward-looking cybersecurity team and are seeking a highly skilled,
technology-savvy, hands-on and result driven Lead Security Engineer to join our high-
performing team. This is a key role in shaping our AI First Security Transformation
strategy to protect Natera future systems across AWS, GCP, Networks, OT, and SaaS.
In this dynamic, fast-paced environment, you will be responsible for designing,
implementing, and automating secure, scalable solutions across cloud, containerized,
and on-premises environments. You will use the latest technologies to develop security
solutions to enhance Natera’s security posture.

To be successful in this role, deep understanding of security controls across multiple
domains and solid hands-on experience in security automation are must have. Besides
solid cybersecurity domain knowledge, the candidate should be proficient in Python,
Java, and other comparable automation languages, expert level experience in AI
assisted programming and automation, to drive cybersecurity operational efficiency.
As the outcome, this position will deliver the secure automation and integration across
different platforms and clouds, while ensuring alignment with enterprise security
standards. Collaboration with cross-functional teams is essential to embed security
across the entire technology stack.

PRIMARY RESPONSIBILITIES:

● Lead the development and implementation of enterprise-wide security automation
strategies and frameworks
● Design, build, and run security automation solutions for AWS and on-premises
environments, with a strong emphasis on Zero Trust principles, identity and access
management (IAM), encryption, secure access controls, SIEM and XDR platforms.
● Partner with Engineering, DevOps, IT, and Compliance teams to ensure security
automation adoption and security-by-default principles are embedded into
infrastructure and applications

● Collaborate with DevOps and engineering teams to embed security automation into
CI/CD workflows and Infrastructure-as-Code (IaC) processes
● Establish and enforce security best practices in containerized environments (e.g.,
EKS, ECS) and AI-enabled applications, including workload protection, runtime
monitoring, and secrets management.
● Support the secure design, development, and deployment of AI/ML solutions and
data pipelines, ensuring robust controls around model access, training data, and
infrastructure
● Champion the use of security automation and playbooks using tools such as Python,
Lambda, Terraform, and others to streamline security testing, threat detection, and
remediation workflows.
● Evaluate and recommend security tools, platforms, and automation approaches that
align with business goals and security requirements.
● Work closely with the Incident Response team to ensure security automation is
enabled to efficiently address the current and emerging threat landscapes.
● Participate in design reviews, conduct threat modeling exercises, and contribute to
architecture governance and decision-making processes.
● Influence the development of security policies and standards to align with industry
best practices and regulatory frameworks (e.g., HIPAA, NIST, CISA, FDA).
● Stay current on industry trends, emerging threats (including AI-driven threats), and
technologies to continuously enhance the organization’s security posture.
● Mentor and provide guidance to security engineers and developers on security
automation and related AI technologies.

QUALIFICATIONS:

● Bachelor’s degree in Computer Science, Information Security, Engineering, or a
related field required
● Master’s degree in Computer Science, specifically in Information Security or a
related discipline is strongly preferred
● Minimum of 12 years of progressive experience in cybersecurity, including at least 5
years in a security engineering/automation or senior-level engineering role
● Hands-on experience with security automation is a must have, along with proficiency
in AI assisted development, familiar with Python, Cursor, Lambda, Terraform, or a
comparable scripting and infrastructure-as-code (IaC) tool, to drive security
operational efficiency and consistency.
● Deep experience in design, implement, and run large scale enterprise solutions
(ideally in Healthcare or financial sectors)
● Proven ability to design and implement security controls aligned with compliance
frameworks such as HIPAA, NIST, and CIS.
● Extensive hands-on experience in AWS cloud security, network security, with
extended knowledge on Zero Trust, Data Protection, and Appsec
● Strong understanding of enterprise identity and access management (IAM) systems,
Data Protection, including platforms like Okta, SailPoint, VDI, and Active Directory
(AD).
● Expert experience with SIEM platforms, XDR, and cloud-native threat detection
tools.
● Expert experience in web application security, OWASP, API security, and secure
design and testing
● Industry certifications preferred: CISSP, CCSP, AWS Certified Security – Specialty,
AWS Certified Solutions Architect – Professional, or AWS Certified Advanced
Networking – Specialty (or equivalent).

KNOWLEDGE, SKILLS, AND ABILITIES:

● Excellent written and verbal communication skills, able to translate complex security
concepts for technical and non-technical audiences.
● Ability to influence stakeholders and drive alignment across multiple teams.
● Strategic thinker with a passion for security innovation, continuous improvement, and
building scalable defenses.