ROME Therapeutics is developing novel therapies for cancer and autoimmune diseases by harnessing the power of the repeatome – vast stretches of uncharted genetic material that have long been dismissed as the “dark genome.” With several drug targets identified and multiple discovery programs underway, ROME is moving rapidly to leverage this new frontier in biology. To lead this exploration, ROME has assembled a team of world-class leaders across fields including oncology, immunology, virology, chemistry and machine learning. ROME is based in Boston, MA. 

ROME Therapeutics is seeking an experienced Senior Director, Program Management, with a focus on Early Development - shaping and executing drug development strategies from Development Candidate declaration through clinical proof of concept - including IND-enabling, translational and early clinical studies. The position offers an exciting opportunity for a self-motivated and versatile individual familiar with multiple aspects of pre-clinical and early clinical development, including GMP scale-up, pre-clinical tox, translational studies, IND filings and clinical trial initiation. Responsibilities include providing program management support for ROME’s lead program and serving as a key member of the Program Core Team that is responsible for setting Program development strategy and ensuring flawless execution. The Early Development Program Manager is accountable for elements of the cross-functional planning and execution, including operational strategy, management of timelines, cost, quality, and risk assessment and mitigation. The individual will play an instrumental role in working cross functionally, across the entire organization, to organize and advance critical programs, and in enhancing overall program management capabilities at ROME.

What You’ll Do

  • Partner with the Program Lead to formulate program strategy and drive/coordinate cross-functional planning and execution
  • Serve as an integrator on the Program Core Team and across the organization to ensure alignment on implementation of program strategy
  • Create and maintain a cross-functional short and long-term program development plan, with goals, timeline and budget for each program
  • Ensure progress vs. plan, proactively identifying and facilitating team review of program risks and ensure mitigation plans are developed and implemented; work with the team to develop plans that enable parallel tracking when warranted
  • Negotiate CRO and consulting agreements, with respect to pricing, payment schedules and other
  • Develop and coordinate resource and budget planning across functions to assure adequate resources are applied to the project and any changes are highlighted appropriately
  • Facilitate effective, science-based business decisions including development of scenarios as needed, highlighting interdependencies and downstream impacts (including but not limited to timelines and budget) of strategic decisions
  • Ensure appropriate Program Core Team membership during the progression of the program
  • Execute program management activities including setting meeting agendas that appropriately prioritize program needs, effectively documenting meetings with directive action items, and ensuring full communication of relevant information to maintain team alignment
  • Communicate to team and stakeholders in a transparent and timely manner; engage with stakeholders at all levels of the organization to solicit input and feedback, incorporate learnings into team direction setting, problem resolution and lessons learned activities
  • Develop and maintain a high performing operational approach including effective team building and conflict management; identify and manage situations requiring escalation
  • As project management subject matter expert, understand best practices, identify gaps and challenges, implement efficiencies and improved ways of working
  • Create a team environment that encourages cross-functional engagement, cooperation, accountability, and satisfaction

What You’ll Bring

  • Advanced degree in Life Sciences, Chemical Sciences, Physical sciences or other relevant discipline, MS/Ph.D. preferred
  • 12+ years of multidiscipline clinical experience at a biopharmaceutical company in areas of IND-enabling pre-clinical work, clinical trial planning, execution, and reporting and/or regulatory submissions with at least 2 years in a program management or similar role
  • Demonstrated competency in early phase drug development with solid understanding of disease area and drug development pathways
  • Proven track record, having supported at least 2 IND filings
  • Demonstrated ability to drive cross-functional team success and achievement of timelines and goals in the context of a biopharmaceutical therapeutic development program
  • Excellent project management skills – driving execution while balancing speed, quality, risk and cost, experience with Agile or Scrum process improvement strategies a plus
  • Strong ability to identify short- and long-term program needs, manage and mitigate risk, creatively formulate plans with team input, achieve decisions/alignment and organize resources
  • Experience resolving complex problems and managing difficult stakeholder situations
  • Ability to lead the development of critical path analyses and scenario planning
  • Strong communication skills, with ability to integrate and succinctly summarize, and effectively tailor messages to audience, including senior leaders
  • Demonstration of self-awareness, understanding and acknowledgement of own strengths and limitations and respect for others’ preferences and expertise
  • Ability to handle complexity, prioritize and multi-task program demands
  • Proficiency in Microsoft Outlook, Word, Excel, PowerPoint, GANTT chart software (MS Project, SmartSheet or similar tool)
  • Experience in autoimmune disease and/or oncology (strongly preferred)
  • Knowledge of global regulatory guidelines (preferred)
  • Demonstrated success working across internal and external teams (CROs, academic collaborators, etc.), an established network of CROS and consultants is a plus
  • Willingness to work in a hybrid (in-person/remote) work environment as needed
  • Vaccination against COVID-19 is mandatory, subject to medical and religious accommodations, and proof of vaccination must be provided to ROME
  • This role can be remote, hybrid or onsite

Who You’ll Work With

All Roman citizens exemplify our core values.  Romans are encouraged to BE BOLD, DELIVER EXCELLENCE and to CARE DEEPLY in our pursuit of discovering and delivering medicines to patients in need. Relentless curiosity means that we continually strive to improve, learn, and grow by asking questions, seeking knowledge, and stretching beyond our comfort zone. We rely on each other to know our stuff, follow through and to ‘GSD – get stuff done’. We are inspired to operate with respect and kindness, valuing differences and authenticity.

Compensation and Benefits

Rome prides itself on competitive compensation.  We also offer comprehensive health benefits, unlimited vacation, a flexible work approach and 12 weeks of parental leave!

Rome Therapeutics is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status.

Apply for this Job

* Required
resume chosen  
(File types: pdf, doc, docx, txt, rtf)
cover_letter chosen  
(File types: pdf, doc, docx, txt, rtf)
When autocomplete results are available use up and down arrows to review
+ Add Another Education

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in ROME Therapeutics’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Form CC-305

OMB Control Number 1250-0005

Expires 05/31/2023

Voluntary Self-Identification of Disability

Why are you being asked to complete this form?

We are a federal contractor or subcontractor required by law to provide equal employment opportunity to qualified people with disabilities. We are also required to measure our progress toward having at least 7% of our workforce be individuals with disabilities. To do this, we must ask applicants and employees if they have a disability or have ever had a disability. Because a person may become disabled at any time, we ask all of our employees to update their information at least every five years.

Identifying yourself as an individual with a disability is voluntary, and we hope that you will choose to do so. Your answer will be maintained confidentially and not be seen by selecting officials or anyone else involved in making personnel decisions. Completing the form will not negatively impact you in any way, regardless of whether you have self-identified in the past. For more information about this form or the equal employment obligations of federal contractors under Section 503 of the Rehabilitation Act, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at

How do you know if you have a disability?

You are considered to have a disability if you have a physical or mental impairment or medical condition that substantially limits a major life activity, or if you have a history or record of such an impairment or medical condition.

Disabilities include, but are not limited to:

  • Autism
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, or HIV/AIDS
  • Blind or low vision
  • Cancer
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or hard of hearing
  • Depression or anxiety
  • Diabetes
  • Epilepsy
  • Gastrointestinal disorders, for example, Crohn's Disease, or irritable bowel syndrome
  • Intellectual disability
  • Missing limbs or partially missing limbs
  • Nervous system condition for example, migraine headaches, Parkinson’s disease, or Multiple sclerosis (MS)
  • Psychiatric condition, for example, bipolar disorder, schizophrenia, PTSD, or major depression

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.