Senior Director, Development Information Systems

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are seeking an experienced life sciences technology professional to lead the planning, implementation, and ongoing support of technology solutions enabling success across Clinical Development, Regulatory Affairs, Medical Safety, Quality, and Pharmaceutical Development & Manufacturing.  This critical leadership position, reporting to the VP of R&D Information Operations, will serve as the primary liaison between these business units and Information Sciences (IS), ensuring scalable, compliant, and business-aligned systems are in place as we advance toward commercialization. In this role you will:

• Build and maintain strong relationships with functional leaders in Clinical Development, Regulatory Affairs, Medical Safety, Quality, and Pharmaceutical Development & Manufacturing to understand their strategic goals and translate them into robust technology roadmaps.

• Lead and manage the technology portfolio of systems supporting regulated processes, ensuring scalability, compliance, and operational efficiency in preparation for commercial launch.

• Serve as the subject matter expert (SME) and IT thought partner for digital transformation initiatives within regulated domains.

• Oversee planning, budgeting, execution, delivery, and maintenance of key systems initiatives (e.g., CTMS, RIMS, PV Safety DB, QMS).

• Ensure systems are implemented in alignment with GxP and regulatory standards, including 21 CFR Part 11, GAMP5, and data integrity principles.

• Drive system governance, lifecycle management, and change control processes across all supported functions.

• Manage vendor relationships and SaaS contracts to optimize performance and compliance.

• Build, lead, and mentor a high-performing team of IT professionals and service providers.

• Ensure all supported systems meet regulatory, cybersecurity, and data privacy requirements.

• Partner with Quality, Validation, and Compliance to maintain inspection readiness across all technology-enabled processes.

Required Skills, Experience and Education:

• Minimum 13+ years in the pharmaceutical, biotechnology, or life sciences sector, including at least 6 of those years in a leadership role.

• Minimum 5+ years supporting Clinical, Regulatory, and Quality information systems.

• Proven track record of delivering and supporting GxP-compliant systems in a regulated environment.

• Hands-on experience with key platforms such as Veeva Vault (QMS, Quality Docs & Training, RIMS), NetSuite, Tracelink, Argus, Trial Interactive and CTMS.

• Deep understanding of SDLC, validation, and regulatory requirements applicable to clinical-stage and commercializing organizations.

• Strong stakeholder engagement, communication, and vendor management skills.

• Bachelor’s degree in Information Systems, Life Sciences, or related field required.

Preferred Skills: 

• Experience supporting a company through late-stage clinical development into commercialization.

• Ability to lead in a fast-paced, cross-functional, and evolving environment.

• Familiarity with ITIL, Agile, and project portfolio management methodologies.

• Master’s degree or MBA preferred. #LI-Hybrid  #LI-YG1