Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity: 

As a key member of the Biology team, you will: 

  • Independently conduct key experiments to support new target identification and validation efforts

  • Contribute to the development of and perform in vitro and cell-based assays to support identification of tractable chemical matter targeting new oncogenic targets in RAS-driven cancers

  • Apply various cellular, molecular, and genetic techniques to characterize and enhance our mechanistic understanding of novel anti-cancer agents

  • Maintain cultures of multiple human cancer cell lines simultaneously to support experimental efforts 

  • Perform various cell-based assays to interrogate effects of inhibitors on signaling pathways

  • Perform microplate-based quantitative assays using reagent kits

  • Analyze and interpret experimental data, formulate testable hypotheses and propose follow up experiments within project scope, and present results at internal meetings

  • Collaborate with team members to generate novel insights into key drivers of RAS-driven cancers

Required Experience, Skills, and Education: 

  • Bachelor’s degree or Master’s degree in Cell/Molecular Biology, Biochemistry, Biology, Genetics, or related field 

  • 6+ years of experience in an industry position or academic lab involving cell/tissue culture and cell/molecular biology OR 3-5 years of experience with a Master’s degree

  • Demonstrated proficiency with a wide range of cell and molecular biology techniques (e.g., cell line engineering, SDS-PAGE/Western blot, molecular cloning, DNA/RNA preparation, PCR, qPCR, etc.)

  • Proficiency with cell/tissue culture, including the ability to maintain multiple human cancer cell lines simultaneously with strong aseptic technique

  • Rigorous, detail-oriented, and quantitative experimentalist

  • Proven ability to proactively and independently problem solve with minimum guidance

  • Highly organized, with excellent record keeping and written/verbal communication skills

  • Demonstrated ability to multi-task, prioritize, and complete tasks efficiently to meet project deadlines

  • Innovative and adaptable team-player with an eagerness to learn new techniques

Note: This is a lab-based role. Therefore, it is expected that the team member be on-site 5 days per week.

Preferred Skills:

  • Demonstrated proficiency with relevant assay readout technologies (e.g., CellTiter-Glo, AlphaLISA, MSD)

  • Experience with automation (e.g., robotic liquid handlers, cell seeders, etc.)

  • Familiarity with data processing, curve fitting, and visualization tools to analyze small and large datasets (e.g., GraphPad Prism, Genedata Screener, D360, or Spotfire)

The base salary range for this temporary position is $45.00 to $50.00 for candidates based at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the minimum and maximum salary for the position in Redwood City and will be adjusted for the local market a candidate is based. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

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