Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
The Opportunity:
The DMPK Scientist II will be a key member of the Drug Metabolism and Pharmacokinetics (DMPK) team within the Nonclinical Development and Clinical Pharmacology (NDCP) department.
The DMPK Scientist will:
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Participate in the discovery of novel inhibitors of frontier oncology targets by planning and implementing DMPK strategies to support project decisions for advancing small molecule programs.
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Organize, analyze, and generate hypotheses from available data and literature. Explore innovative research to apply the principles of drug distribution and elimination, PKPD relationships, etc.
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Incorporate new concepts and advanced experimental techniques into human dose predictions with the support of mathematical models. Implement the preclinical strategy for predicting human efficacious exposure ranges and safety margins.
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Represent DMPK functional area on multi-disciplinary teams. Develop, design, and manage the ADME/PK studies at CROs in a timely manner, and present results at internal meetings and cross-functional meetings.
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Monitor discovery DMPK studies at CROs. Author or review DMPK sections of regulatory submissions and respond to questions from regulatory agencies.
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Collaborated across functional areas, e.g., Biology/Cancer Pharmacology, Clinical Pharmacology, Medicinal Chemistry, Pharmaceutical Development, Toxicology, and Translational Research.
Required Experience, Skills, and Education:
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A highly motivated individual with a Ph.D. in Pharmaceutic Sciences or a related scientific discipline, with a minimum of 2 years post-graduation experience.
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Solid understanding of ADME principles, and hands-on experience in conducting in vitro and in vivo ADME/PK assays.
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Knowledge and experience in the application of PK and basic compartmental modeling software.
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Excellent verbal and written communication, problem-solving, and critical thinking skills.
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Thrives in a collaborative team setting and is driven by a desire to be innovative in a highly energetic and fast-paced environment.
Preferred Skills:
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Pharmaceutical or biotech industry experience post-Ph.D. is preferred.
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Prior experience with small molecule drug discovery programs preferred
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Prior experience in the field of oncology drug development is a plus.
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Experience supporting cross-functional project teams preferred.
The base salary range for this full-time position is $120,000 to $158,000 for candidates based at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the minimum and maximum salary for the position in Redwood City and will be adjusted for the local market a candidate is based. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.
Please note that base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.
Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.
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