Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

Revolution Medicines Senior Medical Directors are responsible for formulating clinical development strategy and ensuring effective execution of this plan for the assigned molecule(s)/combination(s)/indication(s).  Revolution Medicines has a robust research pipeline from discovery to clinic, and we are working rigorously to leverage this for the greatest possible impact for patients. As a clinician and scientist, you will be bridging the basic research with clinical development strategy in this scientifically rich environment.

In addition, the Senior Medical Director will have responsibilities in:

Clinical Development Planning

  • Maintains the highest standards of scientific and clinical knowledge in the specific therapeutic area(s) of assignment.

  • Stays informed and up to date of internal and external developments, trends, and other dynamics relevant to the clinical development plan, and maintains a current view of the relevant disease area(s) to inform strategy.

  • Collaborates with external stakeholders such as clinical investigators and scientists.

  • Participates in the Clinical Development Steering Team to review, discuss, and provide clinical and scientific input regarding early clinical development plans company/portfolio wide.

  • Works with external investigators to advise on and evaluate Investigator Sponsored Trials.

Clinical Development Implementation

  • Provides the clinical and expert input in the development of clinical sections of Investigator Brochures, presentations, and other materials.

  • Regularly engages with the relevant external investigators; participates in the identification and selection of appropriate external investigators and sites.

  • Acts as the medical monitor for assigned studies.

  • Conducts ongoing reviews of medical/safety data.

  • Collaborates within a multidisciplinary team including biostatisticians and programmers to develop study analytics and data management plans.

  • Collaborates with the Translational Medicine team to strategize, design, and implement biomarker plans.

  • Reviews study data to ensure correct medical/scientific data interpretation for interim and final study reporting.

  • Collaborates with relevant team members to support regulatory interactions such as IND filing, intermittent safety updates, and End of Phase 1 Meetings.

Required Experience, Skills, and Education:

  • D. or M.D./Ph.D. with relevant clinical training required. M.D./Ph.D. with oncology relevant postdoctoral training and/or research experience a plus.

  • Minimum 10+ years’ experience in pharma/biotech clinical development OR is a recognized expert in the field.

  • Experience working with the principles and techniques of data analysis, interpretation, and clinical relevance.

  • A dedication to the RevMed core values:

    • Tireless Commitment to Patients.

    • Transformative Science.

    • Exceptional Together.

    • Total Integrity.

    • Inclusiveness and Fairness.

  • Impeccable sense of ethics and scientific rigor.

  • Excellent judgment and decision-making skills with outstanding attention to detail.

  • Curiosity and a strong drive to grow.

  • Strong written & verbal communication with good interpersonal and influencing skills.

  • Excellent project management skills. Ability to prioritize multiple tasks and goals to ensure their timely and effective completion.

Preferred Skills:

  • Recognized expert in the field.

  • Academic/teaching background a plus.

  • Prior medical monitoring experience.

  • Phase III experience as medical monitor or clinical scientist.

  • Option to travel globally for conferences (<15%)

The expected salary range for this role is $300,000 to $360,000. An individual’s position within the range may be influenced by multiple factors, including skills and experience in role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

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