Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

To aid in this mission, the Translational Medicine (TM) team at RevMed is seeking a highly motivated, scientifically creative, and collaborative Senior Scientist to work in a fast-paced environment within a cross-functional team. You will be a highly motivated scientist, dedicated to biomarker discovery, clinical biomarker development, implementation, and interpretation to help advance our oncology pipeline. You will be responsible for developing and executing biomarker strategies utilizing state-of-the-art technologies for pharmacodynamic response, proof-of-mechanism, and patient stratification/selection. A strong understanding of tumor biology, molecular pathways, genomic techniques, and the ability to analyze and interpret complex data sets will be key strengths. You will have the opportunity to contribute scientifically across the portfolio to programs at various clinical development stages.

Specifically, you will be responsible for:

  • Define and execute translational and biomarker strategies for Revolution Medicine’s clinical-stage oncology programs with a focus on mechanism of action, target engagement, establishment of PK/PD/efficacy relationships, patient selection strategies and understanding mechanisms of intrinsic and acquired resistance.

  • Ensure that clinical biomarker plans are developed and implemented efficiently and aligned with the strategic needs of the program.

  • Manage external biomarker analysis at contract research organizations (CROs) including experimental design, fit-for-purpose validation, budgeting, timelines, oversight of clinical implementation, and data analysis during trial conduct.

  • Collaborate with Translational Medicine team members in biomarker operations and clinical bioinformatics on executing biomarker plans.

  • Evaluate new technologies to enable exploratory biomarkers.

  • Represent Translational Medicine within project/program teams; analyze, interpret, and present biomarker results, meet project/program milestones for TM responsibilities.

  • Contribute to the development of clinical protocols, laboratory manuals, regulatory submissions, abstracts, and publications.

  • Effectively collaborate across internal functions including translational sciences, clinical development, clinical operations, biostatistics, data management, and clinical pharmacology to ensure successful execution in the clinic.

Required Experience, Skills, and Education:

  • A Ph.D. in cancer biology, cell/ molecular biology or equivalent with 3+ years of post-doctoral and/or industry experience, or an M.S. with 6+ years of industry experience. Experience in Translational Medicine with clinical-stage oncology drug development is highly desirable. Title will be commensurate with experience.

  • Demonstrated knowledge of clinically relevant biomarker approaches across a range of technology platforms (NGS, RNAseq, IHC, mIF, qPCR/ ddPCR, etc.), and standard analytical tools, Excel, Prism, etc

  • NGS and genomic biomarker data analysis experience is highly preferred.

  • Experience working with central laboratories and CROs supporting biomarker analysis is preferred.

  • Strong interpersonal and communication skills, including ability to write and present biomarker plans and results in a clear and concise manner.

  • A great teammate, who listens effectively and invites response and discussion.

  • A collaborator who communicates in an open, clear, complete, timely and consistent manner

  • Commitment to Revolution Medicines’ Core Values: Tireless Commitment to Patients, Transformative Science, Exceptional Together, Total Integrity, Inclusiveness and Fairness

The expected salary range for this role is $150,000 - $190,000. An individual’s position within the range may be influenced by multiple factors, including skills and experience in role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

 

Apply for this Job

* Required
resume chosen  
Dropbox
(File types: pdf, doc, docx, txt, rtf)
Cancel
cover_letter chosen  
Dropbox
(File types: pdf, doc, docx, txt, rtf)
Cancel
U.S. Standard Demographic Questions

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

We provide applicants the option to share their demographic background to assist with our DE&I efforts. Any information volunteered through the optional survey will not be used in the selection process for the role.

 All candidate demographic data is anonymous for compliance purposes and to reduce unconscious bias in the hiring process. No personal information will be disclosed.

For any questions on how the voluntary information is utilized, please feel free to reach out to talent@revmed.com.

How would you describe your gender identity? (mark all that apply)





How would you describe your racial/ethnic background? (mark all that apply)











How would you describe your sexual orientation? (mark all that apply)








Do you identify as transgender? (Select one)




Do you have a disability or chronic condition (physical, visual, auditory, cognitive, mental, emotional, or other) that substantially limits one or more of your major life activities, including mobility, communication (seeing, hearing, speaking), and learning? (Select one)




Are you a veteran or active member of the United States Armed Forces? (Select one)




Our system has flagged this application as potentially being associated with bot traffic. Please turn off any VPNs, clear your browser cache and cookies, or try submitting your application in a different browser. If this issue persists, please reach out to our support team via our help center.
Please complete the reCAPTCHA above.