Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are looking for a Scientist to help the Discovery Sciences team accelerate our search for new oncology therapeutics. The successful candidate will join a high-performing team of experts in the use of biochemical and biophysical techniques to drive the efficient identification and rapid development of clinically impactful drugs against frontier targets in oncology. They will contribute to our research portfolio from the bench by taking responsibility for developing, validating, and executing critical enabling biochemical and biophysical assays. In addition to generating high-quality experimental data, the candidate will be tasked with the analysis, curation, and dissemination of resulting insights to our research project teams to facilitate the rapid progression of our research initiatives. The successful candidate will possess the following skills, experience, and attributes:

 

Required Experience, Skills, and Education:

  • Proficient in the design, development, and execution of microplate-based in vitro biochemical and biophysical assays suitable for the discovery, validation and mechanistic characterization of fragment and small molecule modulators of oncology protein targets.

  • Conversant in the selection and deployment of appropriate assay readouts like fluorescence polarization, TR-FRET, AlphaScreen, fluorescence, absorbance, and luminescence.

  • Experience designing assays and experiments using mass spectrometry to characterize proteins/therapeutics by intact mass, peptide mapping, TMT tagging, SILAC, or other methods.

  • Experience with delivering robust data in a timely fashion to research discovery teams is critical.

  • Ph.D. in biochemistry, biophysics, chemical biology, enzymology, or related field, with 0-2 years or a similar Master’s degree with 3+ years of drug discovery experience in industry.

  • Rigorous, quantitative, detail-oriented experimentalist with an understanding of statistics.

  • Excellent written and verbal communication skills.

  • Innovative, team-player with high energy, demonstrated willingness to learn in a fast-paced environment.

Preferred Qualifications:

  • Familiarity with data processing and visualization tools to analyze large datasets (e.g. Genedata Screener, KNIME, R, or Vortex) is a plus.

  • Familiarity with ligand observed NMR spectroscopy and/or DEL screening is a plus.

  • Background in kinetic and thermodynamic characterization of ligand binding interactions using ITC, SPR, BLI or other biophysical methods is desirable.

Revolution Medicines currently requires that all personnel and visitors to its offices be fully vaccinated against COVID-19. This position requires full COVID-19 vaccination, subject to applicable law.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition and veteran status.

Apply for this Job

* Required