Location: Pennsylvania, USA  

Reporting to: Senior Scientific Director, Proteomics, Molecular Technology

Key Responsibilities

  • Manage maintenance, quality control and troubleshooting instruments including nanoLCs, Evosep, and mass spectrometers (Orbitrap, Q-TOF, and MALDI).
  • Design and execute various label-free and label-based (SILAC, TMT etc.) MS experiments for proteomics or targeted protein quantification, and provide project-specific data interpretation
  • Stay up to date on proteomics methods and their application technologies including ASMS, CETSA, HDX and chemoproteomics
  • Develop and operate MS-based high-throughput drug screening methods including ASMS and MALDI
  • Develop and optimize sample preparation methods for deep mass spec-based proteome analysis of cells
  • Collaborate with team members to develop optimal experimental design for characterization of protein degraders
  • Integrate into various drug discovery projects and proactively recognize/solve technical and scientific issues.


  • PhD in proteomics, biochemistry, analytical chemistry, or a related field with 2+ years, MS with 5+ years or BS with 10+ years of relevant experience
  • Broad knowledge of the current mass spectrometry proteomics and techniques, with a proven record of success through publications and presentations
  • Expertise in preparing samples, performing liquid chromatography fractionation, running a range of mass spectrometers, and analyzing mass spectrometry data
  • Experience with maintenance, quality control and troubleshooting instruments including, nanoLCs, Evosep, and mass spectrometers
  • Experience in high-throughput drug screening, quantitative biology, or molecular pharmacology will be a plus.
  • Knowledge and experiences in targeted protein degradation preferred
  • Strong teamwork and communication skills that will contribute to a high performing drug discovery team
  • Collaborative, organized, data-driven, and detail-oriented
  • Strong oral and written communication skill

Apply for this Job

* Required
resume chosen  
(File types: pdf, doc, docx, txt, rtf)
cover_letter chosen  
(File types: pdf, doc, docx, txt, rtf)

Please reach out to our support team via our help center.