Octant is a small molecule therapeutics company scaling drug discovery to navigate the complexity of human diseases using an integrated platform combining synthetic biology, genomics, computation and high-throughput chemistry. 

Octant is an equal opportunity company that values diversity, equity, and inclusion. We welcome applicants of all backgrounds. We’re committed to fostering an inclusive and supportive work environment for everyone.


Octant is looking for a Research Associate in High-Throughput Chemistry to help us build huge compound screening libraries to fuel our many drug discovery programs. You're a chemist who loves seeing your hard work and attention to detail have a direct and immediate impact on drug discovery.   As a member of our team, you’ll be directly responsible for building tens of thousands of compounds each week using the latest in automated lab technologies.  You will also be responsible for ensuring the quality of those screening libraries by applying cutting-edge software tools to analyze the volumes of mass spec data that you will be generating.  Additionally, you will be applying the insights that you gain from that work to improve and refine our library assembly processes over time.  Your contributions on our team will help transform how modern drug discovery is done and will be absolutely critical toward advancing our mission of finding new treatments for complex human diseases. 

Do you love working in the lab, have a fondness for learning new things, and are passionate about chemistry?  Do you thrive on getting things done and can navigate the uncertainty of an ever-changing and fast-paced environment?  Then we very much want to talk with you!


  • Be exposed to a variety of state-of-the-art coupling chemistries. 
  • Learn the ropes of working with lab automation, nanoliter-scale liquid dispensers, gloveboxes for air-sensitive reagents and more.
  • Develop a keen intuition for chemical synthesis based on the massive volumes of reaction data you generate. 
  • In short, become an expert at nano-scale high-throughput chemical synthesis. 


  • have a bachelor’s or MS degree in chemistry.
  • have research experience in an academic or industrial setting (hands-on synthetic chemistry lab experience strongly preferred).
  • have experience using LC-MS for the analysis of small organic molecules.
  • are strongly interested in applying advances in robotics and lab automation toward the generation of structurally diverse compound libraries for drug screening. 
  • have experience running experiments in high-density microplate formats like 384 and 1536 well plates.
  • are genuinely energized by working on challenging “high-impact” problems and approach them with a “can do” spirit.
  • are organized, detail-oriented and thrive in a fast-paced, collaborative, team-oriented startup environment.


We are open to varying levels of experience for this role. Someone fresh out of college would likely be responsible for supplying materials to one drug program and could expect to make 70-75k. Someone with 1-2 years of experience would likely support up to two drug discovery campaigns and could expect to make 80-87k. Anyone with 3-5 years of experience would be expected to support multiple discovery programs and contribute to internal development projects. This type of candidate could reasonably make up to 100k.

We also offer health benefits (medical, dental, vision), equity, and 401(k) matching.


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