About Kronos Bio:

Kronos Bio, Inc. is dedicated to the discovery and development of first-in-class therapies that modulate historically undruggable targets. We leverage deep capabilities in high-throughput small molecule microarrays (SMM), targeted protein degradation, and cancer biology in order to identify potent and selective compounds against transcription factors and other central drivers of oncogenic signaling.

Summary of Position

Kronos Bio seeks an experienced, highly motivated, and collaborative Scientist/Sr. Scientist to join our Translation group. In this position within the Clinical Development group, the ideal candidate will utilize deep expertise in oncology and mechanistic understanding of disease biology to support early drug discovery and development programs. This individual will be expected to support translational activities within the laboratory, employing a variety of molecular and cellular techniques to understand mechanism of action (MOA), identify and validate both patient selection and pharmacodynamic biomarkers. Key skills for success include a diverse experimental skill set, a positive and team-centered attitude, a willingness to learn and work collaboratively, and ability to thrive in a fast-paced environment. The candidate should have proven bench level expertise in establishing and performing a wide range of molecular and protein-based assays. The candidate will also be responsible for guiding and overseeing CROs for multiple projects, including overseeing internally developed assay transfers if required. Keeping the company up to date with the latest tools and platforms for both protein/nucleic acid-based markers will also be the candidate’s responsibility. This position offers the opportunity to contribute to both drug discovery and clinical projects in an innovative and fast-paced team environment with tremendous growth opportunity.

Essential Duties and Responsibilities:

  • Lead the development and execution of biomarker assays for target engagement, pharmacodynamics, patient selection strategy, and rational combination partner nomination.
  • Develop and execute translational research plans to elucidate mechanism of action, support discovery of biomarkers in early programs and reverse translation studies for clinical programs.
  • Maintain mammalian cell lines and primary human samples in tissue culture.
  • Use molecular techniques including nucleic acid extraction, RT-PCR, qPCR/ddPCR, western blot, and MSD to characterize cell lines, primary human samples, preclinical and clinical trial samples.
  • Evaluate protein expression in preclinical and clinical trial samples using IF, IHC and/or flow cytometry.
  • Work collaboratively with other scientists within our multi-disciplinary Cambridge research team.
  • Excellent communication and organization skills, maintain accurate, well-organized experimental records.
  • Organize and present experimental results at regular team meetings.
  • Maintain up to date knowledge of advancements in the field including new laboratory techniques/technologies.


  • PhD in biomedical sciences with a focus on oncology and 3+ years of experience in oncology translational research in academia and/or industry.
  • In-depth knowledge of cancer biology and oncogenic signaling pathways is highly desirable.
  • Hands-on experience with protein and cell-based assays, including mammalian tissue culture, IHC/IF, westerns, ELISA, microscopy, and flow cytometry. Experience with digital spatial profiler platform is highly preferred.
  • Hands-on experience with molecular biology technologies (e.g., NGS, expression profiling) is highly desirable.
  • Experience with in-vivo cancer models including CDX, PDX, syngeneic.
  • Proven ability to work independently and design experiments, troubleshoot, interpret, and report data.
  • Highly analytical mind, attention to detail, and organization skills are critical.
  • Collaborative and proactive attitude with excellent written and oral communication skills.
  • Embodies Kronos values; exhibits high degree of integrity and professionalism when interacting with outside investigators and vendors.
  • Entrepreneurial and enjoys working in a fast-paced, creative and resourceful small company environment.


The above statements are intended to describe the general nature and level of work being performed by employees assigned to this classification.  They are not intended to be construed as an exhaustive list of all responsibilities, duties and skills required of employees assigned to this position.




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