Company Summary:  Korro Bio is a privately held biotechnology company focused on the discovery and development of a new class of precision genetic medicines utilizing our propriety RNA editing platform, OPERA. Our portfolio of innovative RNA therapies has the potential to propel genetic medicine beyond rare genetic diseases into larger patient populations with common diseases. Korro enjoys support from a committed group of institutional investors, and recently completed a $116 million Series B financing round to advance our current and future work. We are located in Cambridge, Massachusetts.

We are collaborative and united by a common mission.  We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases.  Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization.  They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work.

Position Summary:  Korro Bio is seeking a motivated and collaborative medicinal chemist to work as a Scientist within the chemistry team. Key contributions to this position include designing and executing chemistry experiments, performing analysis of reaction products using modern techniques, and communicating results to varied audiences within the company. The successful candidate will join an interdisciplinary chemistry team at a growing biotech company at the cutting edge of RNA biology research and will contribute positively to its developing culture. The role will include the potential for significant career growth. This position reports to the Director of oligonucleotide medicinal chemistry and will be based in our Cambridge and Woburn, MA locations. 

Key Responsibilities: 

  • Design, plan, and execute multi-step organic syntheses, purifications, and QC of small molecules such as nucleoside derivatives
  • Suggest synthetic routes for, and manage the outsourcing of small molecule raw materials such as phosphoramidites, targeting ligands, peptides, and linkers
  • Generate new and creative approaches to problem-solving
  • Ensure timely data capture and storage in ELN
  • Provide clear written and verbal updates to project teams and management
  • Serve as chemistry lead on cross-functional project teams
  • Support intellectual property filings with timely execution of studies and experimental write-ups

Required Qualifications:

  • Ph.D. in medicinal chemistry or a related discipline, and 0-3 years of relevant experience in industry or academia

Preferred Experience:

  • A strong background in synthetic chemistry, p SAR analysis
  • Preferred experience with nucleoside/nucleotide chemistry, and oligonucleotide synthesis
  • Experience with bioconjugation methods, including purification, and characterization
  • Oligonucleotide synthesis experience using automated DNA/RNA synthesizers is a plus
  • Demonstrable strong publication and/or patent track record of scientific excellence in the design and synthesis of bioactive compounds
  • Working knowledge of RNA biology and oligonucleotide drug discovery activities
  • Experience managing direct reports and CRO resources
  • Possesses exemplary written and oral communication skills with the ability to clearly articulate ideas
  • Proficient with SciFinder, ChemDraw, and other medicinal chemistry-related software
  • Benefits:  Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending account and a Company-funded health savings account and free parking.

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