Company Summary:  Korro Bio is a privately held biotechnology company focused on the discovery and development of a new class of precision genetic medicines utilizing our propriety RNA editing platform, OPERA. Our portfolio of innovative RNA therapies has the potential to propel genetic medicine beyond rare genetic diseases into larger patient populations with common diseases. Korro enjoys support from a committed group of institutional investors, and recently completed a $116 million Series B financing round to advance our current and future work. We are located in Cambridge, Massachusetts.

We are collaborative and united by a common mission.  We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases.  Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization.  They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work.

Position Summary:  We are looking for a passionate and collaborative Target Computational Biologist to join our Data Science team and work with an enthusiastic team of highly skilled scientists in a dynamic, high growth company. This position reports to the Head of Data Science. The successful candidate will have a strong background in analysis of target prioritization, data analysis, data integration, and data visualization.

Key Responsibilities: 

  • Conducting analysis across multiple target-related datasets. Carry out statistical analysis of the data, and meta-analysis / integrative analysis across various datasets.
  • Conducting data mining of public data resources (ClinVar, GEO, GWAS catalog) and commercial resources / consortia data (UK Biobank, Finngen). Preparation of a data pipeline for analysis / visualization.
  • Collaborate with disease and portfolio team leads in regular target review programs.
  • Building our understanding of target to pursue, as well as off-target analysis to help avoid unwanted side effects.
  • Interact with multidisciplinary project teams as the target data science subject-matter expert. Devise target-centric solutions and apply findings to lead research efforts towards the right targets, and right oligos to engage these targets.
  • Partnering with the software engineers in the DS and IT groups to create an environment for automated target review.
  • Collaborate on project teams and clearly articulate to team members the target/biomarker rationale, how they will advance goals, and what stage they are at in the discovery process.

Required Qualifications:

  • PhD with thesis research in Bioinformatics, Genetics, Genomics, Statistics, or related fields
  • 3+ years of postgraduate work experience in academic or biotech setting
  • Proficiency in the use of data science related programming languages such as Python or R
  • Expertise in computational / statistical analysis and integration of target-related data
  • Familiarity with diverse databases and resources for target prioritization, disease characterization, and biomarker analysis (e.g. UK Biobank, FinnGen, ClinVar, GEO, SRA, Open Targets, etc.)
  • Experience in bioinformatics/genomics pipelines use and implementation
  • Ability to present concepts and data to varied audiences that help drive decision-making
  • Excellent organizational skills, effective manager of tasks and projects
  • Optional experience with / working knowledge of chemistry (in a drug discovery setting)
  • Optional experience with ELN (such as Benchling), LIMS, or other related informatics platforms

Other Knowledge, Experience or Skills recommended

  • Experience with regulatory submission requirements for preclinical and early clinical development.
  • Gene therapy, gene editing, and/or oligonucleotide-related experience is a plus.
  • Solid understanding of drug metabolism, bioanalysis, pharmacokinetics, preclinical pharmacology, PK/PD modeling and clinical study designs.
  • Ability to operate objectively and independently as a leader and as a member of a team.
  • Excellent written and communication skills to a variety of levels/teams- internally and externally.
  • Detail-oriented, with good organizational, prioritization, and time management proficiencies.
  • Must be able to work on multiple projects simultaneously.

Benefits:  Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending account and a Company-funded health savings account and free parking.

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