Company Summary:  Korro Bio is a privately held biotechnology company focused on the discovery and development of a new class of precision genetic medicines utilizing our propriety RNA editing platform, OPERA. Our portfolio of innovative RNA therapies has the potential to propel genetic medicine beyond rare genetic diseases into larger patient populations with common diseases. Korro enjoys support from a committed group of institutional investors, and recently completed a $116 million Series B financing round to advance our current and future work. We are located in Cambridge, Massachusetts.

We are collaborative and united by a common mission.  We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases.  Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization.  They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work.

Position Summary: The Director/Senior Director DMPK will be accountable for the non-clinical pharmacology and drug metabolism components of all drug discovery programs at Korro.   The incumbent will work collaboratively with translational pharmacology, toxicology, and clinical development to support the progression of therapies from late discovery through first in human clinical studies.  The Director/Sr. Director DMPK will also work closely with the chemistry and biology teams to support pharmacology and compound stability inputs to the early discovery process and to support development of the technology platform.  This is a great opportunity to make a difference for patients by driving a new therapeutic modality to the clinic.

Key Responsibilities:

  • Function as a key member of Korro Bio’s scientific leadership team, providing scientific expertise, strategic planning, and goal-oriented execution.
  • Effectively communicate scientific planning, progress and results to Korro’s executive leadership, R&D teams, and external audiences. Additionally, build and develop appropriate relationships with key opinion leaders and SAB members.
  • Represent Pharmacokinetics leader as a member of program, research, preclinical, and clinical teams.
  • Serve as a role model and foster a scientifically rigorous, open and supportive corporate environment
  • Propose ADME/PK, bio-distribution and PK-PD approaches at team discussions of high impact on project progression.
  • Identify and manage consultants and vendors to support ADME, PK and PK/PD studies.
  • Contribute to candidate selection, development strategy, clinical trial design, clinical study protocols and execute and coordinate clinical trial conduct and finalize preclinical and clinical study reports.
  • Partner with the discovery group to optimize preclinical models and inform first in human clinical dosing strategies.
  • Review preclinical study reports, in conjunction with Pharmacokinetics/DMPK and prepare regulatory submission documentation.
  • Author nonclinical toxicology, DMPK and biomarker sections of regulatory documents.
  • Collaborate cross functionally with all relevant areas to support strategic objectives
  • Communicate status updates and program issues to appropriate team members.
  • Participate in budgeting and due diligence activities.
  • Execute deliverables adhering to timelines and budgets.


  • PhD, Pharm. D. or equivalent training in pharmacokinetics, pharmaceutical sciences, or related disciplines.
  • Minimum 15 years of experience in bio/pharmaceutical industry, combined with drug development experience in pharmacokinetics, bio-distribution and PK/PD modeling.

Other Knowledge, Experience or Skills recommended

  • Strong knowledge and hands-on experience with oligonucleotide strategies and methodologies are preferred.
  • Experience with regulatory submissions for small molecules with a focus on preclinical and early clinical development strategy and execution.
  • Experience in nonclinical toxicology is a plus.
  • Gene therapy or gene editing experience is a plus.
  • Solid understanding of drug metabolism, bioanalysis, pharmacokinetics, preclinical pharmacology, PK/PD modeling and clinical study designs.
  • Expertise managing CROs, GLP and other regulated activities.
  • Ability to operate objectively and independently as a leader and as a member of a team.
  • Excellent written and communication skills to a variety of levels/teams- internally and externally.
  • Demonstrated persuasion, influencing and negotiation skills.
  • Detail-oriented, with good organizational, prioritization, and time management proficiencies.
  • Must be able to work on multiple projects simultaneously.

Benefits:  Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending account and a Company-funded health savings account and free parking.

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