Why Join Us?

FogPharma™ is a clinical-stage biopharmaceutical company that seamlessly integrates breakthroughs in bench science and data science to create transformative precision therapeutics for patients suffering from devastating and often fatal diseases such as cancer. FogPharma’ s discovery engine creates Helicon™ therapeutics, which are a new generation of ultra-diverse, highly tunable peptide drugs capable of modulating virtually any protein implicated in disease. Our robust and wholly owned pipeline of programs is currently focused on cancer targets that are intractable to small molecules and biotherapeutics.

The company’s lead program, FOG-001, is a long sought-after blocker of β-catenin:TCF interactions that is currently being evaluated in a Phase 1/2 clinical trial in patients with Wnt/β-catenin signaling pathway-activated solid tumors, including colorectal cancer. FogPharma has raised more than $350 million to date from top investors and is led by an experienced team of industry experts. FogPharma is headquartered in Cambridge, MA.

What’s the opportunity?

This is an exciting opportunity to bring a transformational new modality, our Helicon degraders, to clinical development. We are seeking a creative drug designer with deep expertise in targeted protein degradation. Helicons have the ability to bind tightly to a broad range of targets that traditionally are thought to be undruggable and this provides a unique opportunity to expand the accessible drug space by incorporating degrader and molecular glue functionalities. The successful candidate will be responsible for leading the molecular design in multiple Helicon degrader programs from hit to development candidates. Specifically:  

  • Lead drug design teams applying our AI design platform to facilitate rapid SAR decision-making using state-of-the art methods in medicinal chemistry and targeted protein degradation.
  • Develop and implement an integrated medicinal chemistry strategy, working in concert with partners in Data Science, De Novo Discovery, Molecular and Cellular Biology, DMPK and Pharmacology to reach hit-to-lead and lead optimization goals.
  • Drive progression of lead molecules to pharmacological proof-of-concept studies and development candidate nomination.
  • Collaborate closely with data scientists to evolve machine learning models for acceleration of Helicon degraders platform.
  • Expand our E3 ligase ligands as well as our trimerizers discover platform. Recruit both internal and external partners to generate new research ideas and initiatives.
  • Set ambitious goals and aggressive timelines for reaching key discovery milestones and rapid delivery of first-in-class Helicon™ peptide drugs to patients.
  • Participate in company portfolio and stage-gate reviews, lead the preparation and presentation of program advancement.
  • Collaborate with Lead IP Counsel to formulate intellectual property strategies.

What you will need to be successful in this role:

  • Ph.D. in Chemistry with 15+ years of Industry experience in pharmaceutical/Biotech setting required.
  • Demonstrated expertise and a track record of success in advancing discovery programs involving PROTAC and/or molecular glues from target validation through lead optimization and into clinical development.
  • Fluency in applying computational methods to medicinal chemistry design problems.
  • Innovative thinker with experience as a successful therapeutic program team (co)leader.
  • Solid understanding of cellular/molecular biology, biochemistry, biophysics, mechanisms of drug metabolism, pharmacokinetic and pharmacodynamic sciences.
  • Ability to motivate team and find creative solutions to problems. Demonstrated influence, negotiation, and conflict resolution skills.
  • Capacity to execute tasks independently to achieve company goals on an established timeline.
  • Excellent communication, organization, multi-tasking, flexibility, and team skills.
  • Enthusiasm to work in a dynamic research environment.
  • Able to work on-site and attend in-person meetings.

Core Values

 FogPharma is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

  • Creative. We are creating a whole new class of medicine requiring creativity to solve challenges as they arise, which we have successfully done since the inception of the company.
  • Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
  • Execution-oriented. As we begin clinical development and large-scale manufacturing, the team is balancing creativity and nimbleness with relentless, rigorous and flawless execution.
  • Humble. We fully appreciate that science and technology and policy are in flux, and we balance deep experience with humility to ask fundamental questions and seek newly available solutions.

As an equal opportunity employer, Fog values diversity and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

Apply for this Job

* Required
resume chosen  
Dropbox
(File types: pdf, doc, docx, txt, rtf)
Cancel
cover_letter chosen  
Dropbox
(File types: pdf, doc, docx, txt, rtf)
Cancel

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in FogPharma’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Voluntary Self-Identification of Disability

Form CC-305
Page 1 of 1
OMB Control Number 1250-0005
Expires 04/30/2026

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

  • Alcohol or other substance use disorder (not currently using drugs illegally)
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
  • Blind or low vision
  • Cancer (past or present)
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or serious difficulty hearing
  • Diabetes
  • Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
  • Epilepsy or other seizure disorder
  • Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
  • Intellectual or developmental disability
  • Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
  • Missing limbs or partially missing limbs
  • Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
  • Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
  • Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
  • Partial or complete paralysis (any cause)
  • Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
  • Short stature (dwarfism)
  • Traumatic brain injury

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.

Our system has flagged this application as potentially being associated with bot traffic. Please turn off any VPNs, clear your browser cache and cookies, or try submitting your application in a different browser. If this issue persists, please reach out to our support team via our help center.
Please complete the reCAPTCHA above.