Company Summary:
FL87, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases.
FL87, Inc was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture.
Position Summary:
We are seeking a highly motivated Senior Scientist of Immunology with expertise in T cell biology and in vivo CAR-T therapy development to join our therapeutic discovery team. The candidate will focus on strategic planning and hands-on benchwork using in vitro and ex vivo experimental approaches. This position requires scientific and technical expertise, and experience with pre-clinical disease models, scientific curiosity, and the desire to overcome scientific challenges and drive excellence. This individual will have the opportunity to be a major contributor to our lead program and work in a dynamic and fast-paced entrepreneurial environment as part of a highly collaborative team.
Key Responsibilities:
- Independently design and execute complex in vitro assays to evaluate CAR-T cell function, including multi-color flow cytometry, cytotoxicity assays and other functional readouts
- Independently design and execute in vivo studies, including mice and NHPs and conduct ex vivo analysis of immune cells. Interact with CROs or academic collaborators for in vivo study related activities
- Develop, optimize and troubleshoot experimental protocols, and maintain accurate and timely electronic laboratory notebook records
- Analyze, interpret and communicate experimental data at lab and project team meetings
- Comfortable working both as an independent contributor and as part of a collaborative, multidisciplinary team of scientists
Qualifications:
- Ph.D. in Immunology or related field with 5+ years of relevant experience and 2+ years of industry experience. Title will be commensurate with experience
- Deep expertise in flow cytometry, including panel design, instrument setup, and data analysis
- Experience handing primary T cells, human PBMC, and associated assays to determine T cell function and phenotype
- Experience with mouse models and ex vivo tissue processing and analyses. Experience in humanized mouse models and NHP ex vivo analyses is preferred
- Experience with in in vivo CAR-T is strongly preferred
- Experience with non-viral delivery technologies and nucleic acid modalities is preferred
- Highly motivated to execute at the bench, exceptional organizational, problem-solving, communication, and collaboration skills
Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.