Company Summary

Founded by Flagship Pioneering in 2021, Metaphore aims to unlock breakthroughs that outperform today’s drugs for maximum patient impact, We adapted this idea to drug discovery. MIMIC™, our computationally driven bioplatform that couples machine learning with molecular mimicry, engineers therapeutics to trigger a desired biological response. Our MIMIC platform opens the possibility to develop engineered medicines with specific features to access a range of targets, including those that were previously intractable. Flagship and Metaphore have also just announced a $600M research collaboration with Novo Nordisk to develop up to two next-generation therapeutics for obesity management.

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at

Position Summary

Metaphore Bio is actively seeking a talented and highly motivated Sr. Director/Director of Quantitative Pharmacology to join Translational Sciences team at our lab in Cambridge, MA. The successful candidate will be instrumental in defining and developing therapeutics leveraging Metaphore’s platform as well as leading programs from early discovery through late preclinical development. The role required significant experience in Quantitative Pharmacology, project leadership experience in an industry setting and strong people leadership skills


  • Establish and lead Quantitative Pharmacology at Metaphore Biotechnologies, setting the strategy and vision for the function in the context of the platform, establishing best practices for defining critical pharmacologic and pharmacodynamic properties of therapeutics candidates
  • Perform hands-on planning, design and analysis of results for a variety pharmacometrics studies to inform the development of drug candidates
  • Partner with members of the computational, platform and translational teams to execute PK/PD studies
  • Serve on project teams at various stages of development as a subject matter expert for DMPK Biologics, PK or PK/PD input to the design of nonclinical PK and pharmacology studies.
  • Project leadership of development programs, cross-functionally leading team of computational scientists, protein engineers and translational scientists to effectively and efficiently develop therapeutics candidates
  • Set and manage budget for quantitative pharmacology efforts, including managing in-house and external resources to achieve program specific goals in timely and budget conscious manner



  • PhD +6 years or a MS degree +9 years with a degree in Quantitative Pharmacology (pharmacometrics) or related field.
  • Hands on usage of a broad range of quantitative tools and systems is required as demonstrated by a strong publication record in the field.
  • A proven track record of displaying excellent interpersonal and communication skills both written and oral and ability to communicate complex information succinctly.
  • Extensive experience in mechanistic PK-PD modeling and/ or quantitative pharmacology analyses and/or industry experience in large molecule/biologics discovery and development
  • Hands-on experience in the implementation of PK and PK-PD modeling analysis using software systems such as R, MATLAB/Simbiology, Phoenix/WinNonlin, ADAPT, Monolix is required.
  • Project leadership experience, preferably in context of biologics and/or the development of therapeutics that leverage ML/AI

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

Apply for this Job

* Required

resume chosen  
(File types: pdf, doc, docx, txt, rtf)
cover_letter chosen  
(File types: pdf, doc, docx, txt, rtf)
+ Add another employment

Enter the verification code sent to to confirm you are not a robot, then submit your application.

This application was flagged as potential bot traffic. To resubmit your application, turn off any VPNs, clear the browser's cache and cookies, or try another browser. If you still can't submit it, contact our support team through the help center.