Company Summary:

Laronde is pioneering a platform that offers a completely novel way of modulating human biology. Endless RNA™ (eRNA), is a uniquely engineered RNA that can be programmed to express diverse proteins inside the body. It is long lasting, non-immunogenic, allows for repeat dosing, and offers flexibility in formulation and delivery.

Laronde was founded in 2017 by Flagship Labs, the innovation foundry of Flagship Pioneering. Laronde has raised a record breaking $440 Million in a Series B Financing to advance the development of its eRNA platform. There is a broad pipeline across therapeutic categories with the goal of 100 medicines in 10 years. To learn more, please visit the company’s website at

Position Summary:

We are seeking an Associate Director to provide leadership in understanding eRNA pharmacology for various applications. The role will be responsible supporting DMPK activities to bring multiple DCs across several disease areas into early clinical development. The role will work closely with the disease biology leads to understand eRNA journey to the cell and implications to the pharmacology of the translated protein that the eRNA encodes for. This role will also lead PK model development efforts directly or through a CRO.

Key Responsibilities:

  • Provide thought leadership in the journey of eRNA from point of administration to translation in the cell and tie to PK associated with the protein encoded by it
  • Work closely with eRNA applications team members to disease in vivo studies to assess PK parameters
  • Drive pharmacometric model development either directly or through a CRO to deepen our understanding of eRNA in multiple disease areas
  • Apply deep domain expertise to unlock various eRNA applications and further these to development candidates, IND, and early development
  • Provide a thorough understanding and ability to apply appropriate FDA and ICH guidelines in the design of clinical studies and drug development strategy
  • Work with clinical teams to design PK/PD components in various study designs


  • PhD with a focus in pharmacokinetics, pharmacology, pharmaceutics or other related field
  • 10+ years of drug development experience
  • Hands on PKPD Modeling experience
  • Expertise in pharmacology of biologics; expertise in pharmacology driven by payloads delivered by lipid vehicles is a plus
  • Deep understanding of pharmacometric principles and their application in overall development plans
  • Track record of regulatory filings (INDs) and responding to regulatory agency questions and knowledge of global regulatory requirements and guidance on quantitative analysis
  • Ability to work collaboratively across multiple teams and to synthesize complex information
  • Excellent interpersonal, verbal and written communication skills 

Laronde is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Laronde does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Laronde or its employees is strictly prohibited unless contacted directly by Laronde’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Laronde, and Laronde will not owe any referral or other fees with respect thereto


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