Company Summary:

Tessera Therapeutics is pioneering Gene Writing™— a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy. Tessera Therapeutics was founded by Flagship Pioneering, a life sciences innovation enterprise that conceives, resources, and develops first-in-category companies to transform human health and sustainability.

Position Summary:

We are looking for a Cell Culture and analytics technician to join the Cell Therapy Analytics Team to advance early-stage cell-based unit operations for ex vivo and in vivo cell therapy applications using Tessera’s novel Gene Writing and Gene Rewriting technology. You will work collaboratively across multiple teams within Tessera to produce and characterize primary Immuno-oncology cell banks. Working with the Cell Foundry core team, you will leverage your experience in primary T-cell, HSC and/or iPSC culture to manufacture and characterize cell banks used across research and development to inform cell-based Immuno-oncology efforts with Tessera’s platform Gene Writing technology. You will be part of a team that characterizes and reports how gene writing impacts   various immune, and/or hematopoietic cell subsets. You will work closely with the IO process team to help execute analytics to inform scale-down and scale-up models to generate these cell therapies ex vivo with the goal to bring these therapies to clinic.

Key Responsibilities:

  • The candidate will support development and production of hematopoietic primary cell banks for use in both ex vivo and in vivo Gene Writing platforms.
  • Support characterization assays to inform the biology and process understanding of Gene Writing.
  • Work collaboratively with process and analytics teams to execute developed analytics to inform in-process phenotypic and functional characterization of gene edited cells
  • Assist in interpretation and troubleshooting of analytical assays in various platforms including, flow cytometry, ELISA/MSD, qPCR and ddPCR. Collect and interpret data, prepare experimental reports, and present findings to the IO Process team.
  • Support the development of protocols, test methods, and analytical sampling plans.

Basic Qualifications:

  • BS/MS with 0-2 years of experience in Immunology, Immuno-oncology, cell and gene therapy or related field is required.
  • Experience with research and/or manufacturing scale cell and tissue culture techniques with primary cells or established cell lines is required.
  • Experience with immune cell isolation, enrichment, transduction (viral or non-viral), and expansion.
  • Excellent technical, written, and oral communication skills
  • Has a passion for collaboration and is a dynamic individual hungry to join a thriving, early-stage biotech environment.

Preferred Qualifications:

  • Experience with cell therapy based unit operations, such as CliniMACS, CliniMACS Prodigy, Rotea, Cue, etc…
  • Knowledge and experience with non-viral gene delivery and gene editing.
  • Experience with flow cytometry is preferred.
  • Experience in cell assay development and characterization is a plus.
  • Experience with ELISA/MSD, qPCR, ddPCR and/or high speed cell sorting is a plus.

More About Flagship Pioneering

Flagship Pioneering has conceived of and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Editas Medicine (NASDAQ: EDIT), Omega Therapeutics (NASDAQ: OMGA), Seres Therapeutics (NASDAQ: MCRB), and Indigo Agriculture. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures. In 2021, Flagship Pioneering was ranked 12th globally on Fortune’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

 

Recruitment & Staffing Agencies:  Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates.  The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team.   Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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