Company Summary

Apriori Bio, Inc. (Apriori) is an early-stage biotechnology company with an ambitious and exciting mission: to lay the foundation for Global Pathogen Shield™ protective interventions that that can neutralize a wide range of the most dangerous and rapidly evolving infectious pathogen threats. The company is developing a revolutionary approach to this challenge, based on a powerful combination of deep experimental and computational approaches, and actively recruiting a team of top-tier scientists to build a first-in-category R&D platform with truly global impact.

Apriori is a product of Flagship Pioneering’s venture creation engine, which has also given rise to companies such as Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), and Editas Medicines (NASDAQ: EDIT). Since Flagship’s founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures, resulting in over $34 billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents.

Position Summary:

We are seeking an entrepreneurial, strategic, driven, and visionary scientific expert in immunology and/or viral / molecular biology to join Apriori as our Head of Biology. In this role, you will serve as a critical part of Apriori’s R&D Leadership Team, establishing Apriori as the global leader in designing variant-proof vaccines and antibodies. You will lead a team of world-class scientists to fulfil the broadest vision for Apriori, continuously developing and expanding the platform through state-of-the-art innovation, strategic decision-making, and operational excellence. You will work in close collaboration with other Apriori leaders, including the Head of Computational Sciences, to build a new type of company, successfully combining deep scientific excellence – including high-throughput biology interrogation – with modern computational technologies to enable the systematic design of life-changing medicines. Along with the broader leadership team, you will also partner with key colleagues in the articulation and execution of the company’s scientific, technological and commercial strategies. 

This is a critically important role for Apriori that will include building out the company’s discovery platform and translational immunology capabilities. You will be responsible for the design, construction, optimization and scaling of a suite of molecular tools and innovative assays through which Apriori will evaluate the properties and behavior of viral variant proteins and antibodies.  You will also lead efforts to characterize new immunogens based on their in vivo effects, leveraging a variety of experimental and computational approaches.  You will have a track record of success in inventing and deploying sophisticated new tools for high-volume, high-speed discovery, and deriving unique insights from biological data – particularly as regards protein-protein interactions, protein structure, viral protein function, viral escape and human immune system biology. An essential element of the role will be the ability to collaborate closely with other R&D scientists while adapting to and interpreting new experimental findings and providing experimental guidance in keeping with the company’s objectives.

Key Responsibilities:

  • Lead and build a team focused on the development and deployment of an infrastructure of innovative high-throughput protocols, tools, assays, models and systems to support Apriori’s immunogen design efforts
  • Working closely with molecular biologists, molecular virologists, computational scientists and others within and beyond Apriori, formulate and implement strategies to evaluate and optimize emerging vaccine candidates
  • Coordinate and oversee critical data-generating experiments involving in vitro models as well as human and preclinical samples
  • Drive focused and rapid discovery efforts and early pipeline development; implement strategies to optimize and scale, with a view to maximizing the productivity and value of the company’s technologies
  • Derive new insights from a wide range of datasets and ensure that these are reflected in the company’s broader scientific vision and value proposition
  • Build insights and perspectives to help inform Apriori’s scientific, technological and commercial strategies, including by partnering closely with colleagues across multiple company functions
  • Establish and oversee external projects and scientific collaborators and contract research organizations
  • Spearhead scientific and technical expertise through fluency in relevant scientific literature, attending conferences, and developing relationships with thought leaders, and building on these as necessary to support company objectives
  • Develop relationships with Flagship Pioneering’s broader science community and manage external consultants as needed
  • Communicate insights and conclusions to the scientific team and executive management

Qualifications:

  • PhD or equivalent in molecular biology, cell biology, immunology, infectious disease or a related field
  • 12+ years of postdoctoral experience developing and leveraging tools, assays and high-throughput discovery platforms – including in an industry setting
  • Strong understanding of in vivo models and systems for immunogen discovery and validation
  • Preferably, extensive experience of immunoassay development, application and scaling – including ELISpot, ELISAs, flow cytometry, T- and B-cell assays, etc.
  • Track record of leadership in developing strategic timelines and successfully delivering against company goals
  • Proven ability to troubleshoot challenging technical issues independently and through engagement / leadership of others
  • Good understanding of evolutionary and/or viral biology at the level of molecular systems
  • Extensive experience of high-throughput assay development and/or robotic systems
  • Experience in immunology, virology and/or vaccine design
  • Previous work with biological sequence or protein structure datasets
  • Demonstrated ability in working with highly skilled teams in a fast-paced, entrepreneurial and technical environment
  • Track record of success in developing and growing scientific teams
Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
 
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

Apply for this Job

* Required
  
  
+ Add Another Employment