Principal Research Associate, Biology

Principal Research Associate, Biology

Exo Therapeutics (https://exo-therapeutics.com) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSight™ platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Overview

Exo Therapeutics seeks a highly motivated individual to join a dynamic drug discovery team. This position will focus on developing and applying cell biology techniques to support discovery and development on a key pipeline oncology project. In this lab-based position, the successful candidate will perform cell-based assays and study drug mechanisms of action at the cellular level to help guide the program forward and develop innovative medicine to help patients in need. This individual will also play an integral role as the team grows and expands.

The successful candidate must have five or more years hands-on experience in an academic or industrial setting, desire to work in a fast-paced environment, independent thinking, and outstanding collaboration and communication skills. This individual should have familiarity with use of small molecules in cancer biology, experience in high-through assay development and proficiency in standard molecular biology practices including tissue culture of cancer cell lines, proliferation assay, western blotting, genetic manipulation of cell lines, immunofluorescence, RNA prep, qPCR, protein enrichment (IP) and FACS. Experience with primary human cell isolation, separation and immune assessments considered a plus.  The individual should be able to develop, modify and troubleshoot protocols with limited supervision and deliver quality data in a timely manner. Experience with CRISPR editing, high content imaging, measuring target engagement in in vitro and in vivo samples are a plus.

Responsibilities

Tissue culture of cell lines and primary cells

Develop and execute medium- to high- throughput 96/384 well assays, such as ELISA, quantitative Western, cell viability/death assays to understand compound mechanism of action.

Study target functions in relevant cell models utilizing genetic and chemical tools.

Execute on a wide array of molecular cellular biology techniques to support mechanism of action studies including western blotting, immunofluorescence, genetic manipulation of cell lines, protein enrichment (IP), FACS, RNA prep and qPCR.

Critically analyze and interpret data, and document and communicate results in a timely manner

Presentation and communication of results in project team and departmental meetings.

Contribute effectively to the projects in a multi-disciplinary team environment

Experience with CRISPR editing and/or high content IF cell imaging is a plus.

Education Qualifications

BS/MS with 5+ years of experience or Ph.D with 0-2 years of experience in in Vitro Pharmacology, Cell biology or a related discipline degree with significant proven experience, preferably in the Pharmaceutical or Biotechnology industry

Success Factors

Strong attention to detail and excellent record keeping.

Excellent time-management

Desire and ability to work in a fast paced, cross-functional, flexible and team-oriented environment

Strong interpersonal, verbal, and written communications skills

All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.