Exo Therapeutics (https://exo-therapeutics.com) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSight™ platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases. 

Principal Scientist, Biochemistry

Overview

Exo Therapeutics seeks a highly motivated Principal Scientist with a strong background in biochemistry to serve as a key part of Exo’s efforts to advance our pipeline of drug discovery programs. You will work at a critical juncture of medicinal chemistry and biology with opportunities to contribute to the development of biochemical assays, establishment of small molecule profiling cascades, and the strategic development of Exo’s biochemistry group. Your effort will help us progress our multi-disciplinary programs to deliver on the extraordinary promise of exosite-targeted therapeutics.

As Principal Scientist in Biochemistry, you will help shape the company’s drug discovery pipeline by designing, building, and operating a compound profiling assay cascade for one or more small molecule programs in oncology or inflammation. Exosites are unique protein pockets which require diligence and creativity to fully understand, and you will be a key part of our efforts to do so. We are keen to identify a proactive self-starter of outstanding potential with the technical and collaboration skills to set and achieve a vision of success for our frontline research efforts. As part of a rapidly growing, early-stage company you will have a substantial contribution to build-out and maintenance of our growing laboratory space.

Responsibilities

  • Propose biochemical assays for exosites ranging from validation studies in novel targets to proof-of-mechanism studies in advanced programs, then collaborate closely with medical chemistry, protein expression, and biology groups to establish and deliver those assays.
  • Enable mechanism of action (MoA) studies to understand compound inhibition to drive SAR and support development.
  • Be an expert in effective and efficient screening strategies and guide project teams to assay cascades that best suit the needs of their project.
  • Deliver on critical data room packages, and present findings internally and to broader EXO teams for key Go-No/Go decision making.
  • Oversee junior scientists and manage CRO’s: define scope of work, design experiments, interpret data, trouble shoot, provide next steps.
  • Develop biochemical assays to support identification/validation of new target nomination into the portfolio.
  • Closely interface with program co-leads and leadership teams to align with program strategy, timelines, company goals and deliverables.
  • Contribute your expertise and perspective to ideating new programs and contribute to the advancement of our ExoSight™ technology platform.

Required Qualifications

  • Ph.D. in biochemistry, chemical biology, or related discipline and 8+ years of industrial experience; BS/MS candidates with 14+ years of experience are also welcomed to apply.
  • Proficient in mechanistic biochemistry, particularly novel biochemical assay development.
  • Expert in the strategy of building assay cascades for the characterization of small molecule therapeutics.
  • Able to work effectively as an individual and as a member of multi-disciplinary project teams. Strong track-record of team-based collaboration and managing workflows within a matrixed organization, and with both internal/external stakeholders. Fully capable of coordinating interdepartmental activities and research efforts towards a defined outcome.
  • Strong written and verbal communication skills. High degree of comfort and confidence in analyzing, interpreting, and effectively presenting scientific data at team meetings.
  • Motivated leader, capable of providing strong mentorship to coach and develop more junior team members.
  • Enthusiasm for taking on ambitious scientific challenges and working within dynamic team environment.
  • Expertise in screening adjacent areas such as automation, HTS processes, and assay miniaturization.
  • Experience in oncology or inflammatory diseases is a plus.

 

All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.   

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