About Earli 

The mission of the Biotechnology startup Earli Inc. is large and ambitious: to detect and then cure cancer at its earliest stages, effortlessly and pain free. In other words, ‘make cancer a benign experience’. The technology which grounds the company’s efforts ushers in a new era in “synthetic biomarkers” as a novel methodology to detect cancer and then subsequently localize and then treat the cancer.  The enabling technology utilizes “synthetic biomarkers” as a novel methodology to detect, localize and ultimately destroy cancer.   Founded by Sam Gambhir, Cyriac Roeding and David Suhy, the company is well funded by world-class entrepreneurs and venture capital firms. Earli, Inc. is currently based in Redwood City, California. 

Who You Are

  • You share our same sense of dedication, scientific passion and entrepreneurial spirit 
  • You work well in a fast-paced and extremely focused startup environment 
  • You are not only smart, but clever and constantly think outside the box 
  • You are able to make logical decisions in an instant when there is little time to evaluate 
  • You are a natural communicator and relationship builder 
  • You stay calm under high pressure and stress 
  • You have the ability to multi-task in a serious way, with an extreme attention to detail 
  • You become a representative of the core DNA of the company through who you are 

The Position

Earli, Inc. is currently seeking motivated Senior Scientist Molecular Imaging (PET-CT) candidates. 

Your Primary Responsibilities

Earli’s platform technology uses cancer-activated gene expression to usurp the dysregulated pathways that lead to malignancy. In this position, you will be leveraging this unique platform for the cancer-activated expression of PET reporter genes and synthetic targets for the purpose of developing imaging agents and theranostic approaches. Within this context, you will:

  • Assist in the development of improved molecular imaging techniques using expressed PET reporter genes in preclinical cancer models and characterizing the outcomes of the experiments with a view towards human clinical translation.
  • Provide technical leadership in obtaining and interpreting data sets from quantitative analysis of PET imaging.
  • Conduct and communicate complex statistical analyses of medical imaging studies to support trial design and registration activities.
  • Work with bioinformatics team to optimize image analysis and improve quality, develop co-registration tools, incorporate partial-volume correction, iterative image reconstruction, etc.
  • Assist in the development innovative ideas for novel PET reporter genes and tracers.
  • Prepare high quality analytic documentation, such as project reports and manuscripts to support publications and regulatory filings. 

Your Required Experience, Knowledge and Skills

  • M.S. or Ph.D. degree in Biophysics, Medical Physics, Bioengineering, Biology, Biochemistry, or a related degree.
  • At least 5+ years of strong technical experience working in a post-graduate setting in industry or an academic lab, with a proven track record of expertise with medical imaging (PET, CT, SPECT, etc.) and image segmentation in preclinical animal models.
  • Demonstrated success with the leading the design and interpretation of external in vivo experiments to explore diagnostic imaging agents and the therapeutic potential of radiotherapeutics in relevant oncology models.
  • Expertise in physical dosimetry and mathematical dose calculations of a wide variety of tracers and labels is highly desired.
  • Previous experience with AI and ML-based techniques is a plus.
  • Previous experience with QC and interpretation of data from PET imaging analyses tools such as PMOD, MIM, APPIAN or VIVOQUANT platforms is required.
  • A background in synthetic biology and/or the use of PET reporter genes would be helpful.
  • Be a go-getter, hands-on kind of person.
  • Keen eye for detail, both with experiments and documentation.
  • Excellent communication skills and ability to work with a diverse interdisciplinary team.
  • Team player and not shy to roll up the sleeves if needed.

Why You Should Apply

  • Outstanding opportunity to work with some of the top business and scientific minds in the Bay area;
  • Competitive compensation package;
  • Rare opportunity to make a significant impact in the growth and development of a well-funded and scientifically sound start-up.

If interested in applying, please attach a CV or have a well-developed LinkedIn profile for us to be able to assess your background. 

We look forward to hearing from you!

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