Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.
Position Description:
Calico is seeking a scientist to join our Protein Science team to support Calico’s research in aging and age-related diseases. The candidate will work closely with computational modeling scientists to investigate structure-activity relationships to drive therapeutic design and optimization. The ideal candidate must be highly motivated, detail-oriented, work autonomously with a variety of experimental techniques, and be comfortable presenting results to cross-functional teams.
Position Requirements:
Ph.D. in biochemistry, biology, structural biology, biophysics, chemical biology or a related discipline and 0-2 years of additional training in an industry or academic setting
A track record of experience in protein biochemistry as evidenced by high profile publications
Strong experience designing and conducting in-vitro protein activity assays using a variety of formats such as fluorescence and western blot-based
Experience with enzyme kinetics and evaluating IC50 values for various inhibitor modalities (small molecules, peptides, and biologics) would be an advantage
Experience with binding assays using SPR, BLI, or ITC would be an advantage
Strong expertise in protein construct design, protein expression in bacteria and mammalian cells, and protein purification of secreted and intracellular proteins using AKTA FPLCs and various chromatography procedures is required
A thorough understanding of protein structure and function and experience with molecular viewing software (PyMOL or Chimera) is required and an understanding of experimental structure determination by X-ray crystallography or cryo-EM would be an advantage
Experience using an electronic notebook would be a plus
Experience working with CROs would be a plus
Accountable, detail-oriented, and able to multitask
Self-motivated and able to work independently in a cross-functional team environment
Must be willing to work onsite five days per week
The estimated base salary range for this role is $127,000 - $135,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.