Calico is seeking an energetic, enthusiastic and highly motivated Postdoctoral Fellow to join the Harding lab to work on a project at the intersection of immuno-oncology and aging biology. This work will complement our lab’s focus on uncovering new modalities for immunotherapy. The researcher will be deeply involved in understanding the interplay between aging, metabolism, immune system function, and cancer biology, utilizing state-of-the-art technologies and methodologies. The postdoc will receive comprehensive training and mentorship with a unique opportunity to collaborate with Calico’s diverse scientific community within the oncology, aging, and discovery technology groups.
Responsibilities:
Conduct experimental research utilizing various tumor models, dietary interventions, immune cell depletion and adoptive transfer techniques
Characterize immune-cell-intrinsic changes through phenotypic, transcriptional, and metabolomic analyses
Investigate role of genes and pathways in modulating immune system function in vivo and in vitro primary cell culture using CRISPR modification, etc.
Collaborate with interdisciplinary teams, including experts in immunology, aging, metabolism, and tumor biology, to integrate and expand research findings
Publish and present research outcomes in scientific journals and conferences, contributing to the broader scientific community
Position Requirements:
PhD in immunology highly preferred; PhD in cancer biology, molecular biology, or a related field acceptable
Hands-on experience with in vivo techniques, including mouse handling/injection, tissue harvest, and isolation of immune cells
Proficiency in standard molecular and cellular laboratory techniques such as flow cytometry, CRISPR, single-cell RNAseq, ELISA, Western Blot, primary cell culture
Curiosity driven with strong analytical and critical thinking skills, with a capacity to conduct independent research
Excellent spoken and written communication skills for effective collaboration and dissemination of research findings
Nice to have:
Technical expertise in the following areas: multi-color flow cytometry, primary immune cell culture, and mouse tumor models
Experience with CRISPR screening technologies, working with genomics datasets, and/or competency in python/R-based data analysis
Background in metabolism research (Seahorse, metabolomics data interpretation)
The estimated base salary for this role is $95,000.
More information on our postdoctoral fellowship program can be found here.