Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X or LinkedIn. 

 

How we work

  • PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
  • COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
  • BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

 

How you’ll contribute:

  • Use scientific, data, and risk-based approaches to clinical and commercial route and process innovation and selection guided by principles process safety and  green chemistry.
  • Manage and coordinate outsourcing efforts at external CROs and CDMOs to ensure high quality and on-time execution.
  • Serve as technology lead for process technology transfers.
  • Collaborate with Drug Product and Analytical colleagues to ensure the Drug Substance physical attributes are understood, controlled, and are appropriate for Drug Product manufacturing.  
  • Ensure stage appropriate data is generated and documented; serve as contributing author of Drug Substance sections of regulatory filings.   
  • Collaborate effectively with internal and external stakeholders to deliver on program objectives. 

 

Skills and experience you’ll bring:

  • Ability to develop data driven crystallization processes based off an understanding and application of fundamental principles.   
  • Experience using statistical and modelling software applicable to Drug Substance Development.   
  • Design and execution of process characterization with cross-functional colleagues, utilizing Quality by Design principles. 
  • Ability to conduct internal lab work, as needed, to support outsourced development.
  • Ph.D. in Chemistry or Chemical Engineering with at least 7 years’ or B.S./ M.S. in Chemistry or Chemical Engineering with at least 12 years’ experience in Drug Substance Development.   
  • Experience with: 
    • Bringing small molecule assets from late discovery through mid-phase clinical trials.  
    • Serving as the Drug Substance lead on fully integrated Chemistry, Manufacturing, and Control (CMC) teams. 
    • Directing CRO and CDMO partners. 
    • Writing and reviewing Drug Substance related technical documents. 
  • Deep understanding of small molecule drug development; understand how CMC disciplines integrate and partners with associated functional areas such as Quality, Non-clinical Safety, Clinical, Regulatory, and Intellectual Property Protection. 
  • In-depth familiarity with phase based GMPs and manufacturing compliance requirements, regulatory guidelines and expectations. 
  • Willingness and ability to work hands-on and with a sense of urgency in a fast-paced, agile environment. 
  • Ability to manage ambiguity, think critically, and make sound, risk-based scientific and business decisions when there is limited information. 
  • Ability to conduct, manage, and communicate risk assessments. 
  • Passion about learning and development to help build a dynamic company at the cutting edge of Targeted Protein Degradation. 

 This position is based in Watertown, MA. 

 

 

Skills and experience not an exact match?:

Go ahead and submit your resume (and a cover letter, if you’d like!).  If this role isn't right for you, we can keep you in mind for future opportunities.

 

                                                                                                                                                                                  

 

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

 

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