We are seeking an experienced Vice President / Senior Medical Director to join the Clinical Development team at Kymera Therapeutics. Reporting to the Senior Vice President, Head of Development, the VP/Senior Medical Director will provide clinical leadership within the company in critical projects and will be a crucial link with investigators and key opinion leaders in the external oncology community. The successful candidate will work closely with these experts, developing the clinical trial strategy and designing clinical trials. This individual will serve as a key strategic and medical point person during the conduct of the trials and will be responsible for monitoring the conduct of clinical trials. In this role, the successful candidate will be responsible for safety monitoring, overseeing patient enrollment, and monitoring of efficacy and other study endpoints. This individual will also be responsible for leading efforts to analyze and present results of the clinical studies. The successful candidate will collaborate closely with other physicians, scientists, regulatory professionals, statisticians, and internal stakeholders to fulfill these responsibilities.  The VP/Sr. Medical Director will respond to inquiries by practitioners and investigators, IRBs, regulatory bodies, and vendors.

Kymera Therapeutics is a publicly listed, clinical stage biotechnology company pioneering the field of targeted protein degradation (TPD) to bring life-changing medicines to patients that need them. Kymera’s Pegasus™ TPD platform harnesses the body’s natural protein recycling machinery to degrade disease-causing proteins, with a focus on undrugged nodes in validated pathways currently inaccessible with conventional therapeutics. As we work toward becoming a fully-integrated biopharmaceutical company, we are growing and strengthening organizational capabilities and evolving our culture. As a result, Kymera has been recognized by both the Boston Globe and the Boston Business Journal as one of Boston’s top workplaces.

In 2023, we plan to continue to advance our leadership in TPD and enhance our capabilities to deliver on the potential of inventing a new class of protein degrader medicines for patients. Kymera is rapidly advancing four clinical stage programs in oncology and immunology, and is positioned to deliver one additional Investigational New Drug Applications (IND) annually. We are also actively advancing a broad pipeline of preclinical programs where TPD has the potential to provide a best-in-class approach, both internally and in collaboration with our partners Sanofi and Vertex Pharmaceuticals.



  • Provides clinical leadership and strategic medical input for all clinical deliverables in critical projects and clinical programs.
  • Collaborates with physicians, scientists, regulatory professionals, biostatisticians, regulatory, executive staff, and others as necessary to develop and execute clinical trials from beginning to end.
  • Drives clinical trial execution to achieve timely completion of clinical studies in collaboration with clinical teams.
  • Designs and develops clinical study protocols and associated clinical study documents and contributes to program level documents such as Investigator Brochures and Clinical Development Plans.
  • Assumes medical responsibility for clinical trials including active participation in real-time medical monitoring of studies, including patient eligibility assessment, study design questions and safety data review.
  • Conducts safety monitoring in collaboration with CRO pharmacovigilance group of active clinical studies.
  • Ensures consistent practices with the highest ethical standards in compliance with internal SOPs, local regulations, and laws.
  • Collaborates with colleagues in Regulatory Affairs, CMC, Toxicology, Research, and Pharmacology to respond to health authority and ethics committee queries.
  • Collaborates with Principal Investigators in the evaluation and assessment and presentation of publications (abstracts, posters, manuscripts) associated with clinical data.
  • Participates in clinical study report writing and review, using medical expertise to identify ways to best analyze and present data.
  • Performs functions in compliance with GCP, and good medical practice.
  • Networks extensively to develop long-term strategic partnerships with thought leaders both internally and externally, in support of the company’s vision.



  •  Medical degree (or equivalent).
  • Board certification/eligibility and clinical experience in oncology or hematology/oncology highly preferred.
  • 8+ years of clinical development experience within the pharmaceutical or biotechnology industry with a focus and strong track record of experience leading oncology clinical trials.
  • Academic oncologists with clinical and research experience relative to the oncology platform will be considered.
  • Strong working knowledge of the clinical drug development process required.
  • Must have a solid understanding of the clinical landscape relevant to oncology patients and health care practitioners in the field.
  • Requires a track record in the conduct of/participation in clinical trials (investigator initiated, company sponsored or cooperative group trials) and their subsequent publications.
  • Requires strong credibility within the US medical community including the ability to reach out to key thought leaders in academia.
  • The demonstrated ability to work in a matrix environment with cross-functional teams is required.



Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics.


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