We are seeking an experienced professional who is passionate about translational science and drug development to join the translational medicine group at Kymera Therapeutics.  This person will be an integral member of a multidisciplinary project team that is applying targeted protein degradation to previously intractable targets. The scientist will help design translational and correlative studies and enable understanding of drug mechanism in different indications by implementing robust biomarker endpoints in preclinical and clinical studies.

Kymera Therapeutics is a clinical stage biotechnology company focused on advancing the field of targeted protein degradation (TPD), a transformative new approach to address previously intractable disease targets. Kymera’s Pegasus™ TPD platform harnesses the body’s natural protein recycling machinery to degrade disease-causing proteins, with a focus on undrugged nodes in validated pathways currently inaccessible with conventional therapeutics. Our mission is to discover, develop, and commercialize transformative therapies while leading the evolution of targeted protein degradation. Kymera’s goal is to become a fully integrated biopharmaceutical company with a pipeline of novel medicines, with an initial focus on immune-inflammatory diseases and oncology.

In 2023, we plan to continue to advance our leadership in TPD and enhance our capabilities to deliver on the potential of inventing a new class of protein degrader medicines for patients. Kymera is rapidly advancing four clinical stage programs in oncology and immunology, and is positioned to deliver one additional Investigational New Drug Applications (IND) annually. We are also actively advancing a broad pipeline of preclinical programs where TPD has the potential to provide a best-in-class approach, both internally and in collaboration with our partners Sanofi and Vertex Pharmaceuticals.

 

Responsibilities:

  • Working with the Translational Lead for any given program, the candidate will leverage subject matter expertise in Oncology and mechanistic understanding of disease biology to support translational medicine strategy; development and testing of robust biomarker hypotheses working cross functionally, for one or more assets spanning preclinical to early clinical development programs.
  • Support discovery & integration of novel mechanistic, pharmacodynamic, predictive, patient selection biomarkers into trial designs to enable clinical proof of mechanism (POM), proof of biology (POB) endpoints.
  • Evaluate new biomarker platforms, develop and validate biomarker assays at outsourced partner laboratories using multiple assay technology platforms (e.g., cell-based assays, molecular assays, single or multiplexed immunoassays, flow cytometry, digital pathology and working knowledge of image analysis; background in IHC/mIF/ histopathological data analyses is a plus). 
  • Partnering with TMED and Clinical Operations colleagues, enable seamless implementation of biomarker assays in the clinic.
  • Support experimental medicine studies as needed, coordinating and organizing reverse translational plans with access to relevant patient samples.
  • Helps review translational medicine-related documentation, including clinical protocols, lab manuals, study reports, abstracts and/or manuscripts and regulatory documents (e.g. IND, IB etc.) 

 

Qualifications:

  • PhD and postdoc in Oncology/Cellular and Molecular Biology/Pharmacology or related discipline with 2 years of industry experience (preferred), or Masters with 5+ years of industry experience or Bachelors plus 7+ years in drug discovery and/or translational medicine required. 
  • Motivated, self-starter, goal-driven, open-minded, creative, collaborative with cross functional skills
  • Strong written & verbal communication skills for presenting data and ideas to multiple stakeholders across disciplines.
  • Implementation translational research studies and clinical biomarker assays utilizing cutting-edge technologies.
  • Hands-on experience with and expert understanding of molecular and cellular techniques, such as PCR, IHC/IF, digital pathology flow cytometry, NGS assays and their application in clinical trials.
  • Ability to design, execute and interpret experiments and communicate experimental results.
  • Track record of working effectively with CROs to design and execute studies.   
  • Experience in validating clinical sites or central labs for implementation of clinical assays preferred.  

 

 

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics.

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