Company Overview 

Fulcrum Therapeutics is a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases in areas of high unmet medical need. Fulcrum’s two lead programs in clinical development are losmapimod, a small molecule for the treatment of facioscapulohumeral muscular dystrophy (FSHD) and pociredir, a small molecule designed to increase expression of fetal hemoglobin for the treatment of sickle cell disease and other hemoglobinopathies. The company’s proprietary product engine identifies drug targets that can modulate gene expression to treat the known root cause of gene mis-expression.


Reporting to the SVP, Business and Corporate Development, the Sr. Director/Director, Alliance Management will be a highly innovative and driven individual with proven relationship management experience that will support all current partnerships, collaborations, and future alliances.


  • Own and be accountable for the partner relationship, at times as de facto lead of external (out-licensed) programs. Build expertise on partner company, including organization/leadership, strategies, financials, priorities, etc.
  • Become Fulcrum “internal expert” on partner company.
  • Ensure success of key alliance goals and that the relationship remains productive.
  • Lead cross-functional team members in preparing for and engaging in interactions with our partners towards successful outcomes (e.g. direction/input for joint steering committee meetings, project-based analyses & recommendations, behind-the-scenes pre-wiring & coordination, etc.).
  • Be familiar and close enough to details of the programs (internally and at the partner) to provide thoughtful direction & counsel to team members on strategy & approach.
  • Liaise with Legal, Finance, Business Development, and cross-functional teams to ensure that key contract terms, including roles & responsibilities, milestones, financial transactions, progress reports, etc. are executed appropriately using an informed & practical point of view when dealing with areas of ambiguity and proactively working to identify & mitigate potential future issues.
  • Create and cascade inter-company communications, develop purposeful agendas, manage key joint committee meetings and document key discussion points & decisions. Conduct regular reviews/meetings with senior management and other functions as appropriate to communicate key issues, milestones, etc. and gather feedback.
  • Build and maintain relationships with key personnel both internally and with alliance partners. Regularly communicate with partner alliance management counterpart and other key partner stakeholders engaging on the various day-to-day issues and opportunities arising from the collaboration.
  • Collaborate with team leadership and other necessary stakeholders to define strategic priorities and drive alignment process. Conduct post-mortem analyses to identify and implement proactive mitigation strategies to minimize crisis management situations.
  • Perform regular alliance audits and “health checks”. Prioritize issues and brainstorm solutions including to maintain high morale across teams and within organizations.
  • This position is hybrid (50% in office) and will be primarily located in Cambridge, 


  • Bachelor’s degree in sciences or related field required, MBA, PhD
  • Minimum of 10 plus years of experience in pharmaceutical or biotechnology industry
  • Drug development knowledge with basic to strong understanding of other functions relevant to the position, which may include Research, Non-Clinical/Early Development, Clinical, Technical Operations/CMC, Regulatory, Medical Affairs and Commercial
  • Applied know-how of key alliance management principles including how to understand/apply contract language, escalate/mitigate issues, and demonstrate creative problem-solving.
  • Excellent interpersonal skills, executive poise and EQ, with ability to lead, engage, focus, negotiate, and resolve conflict internally and externally; demonstrated conflict management skills including de-escalation, mediation, and bargaining preferred.
  • Demonstrated ability to work independently, proactively and with agility in a complex, matrixed environment, dealing well with ambiguity, building internal alignment, influencing others and managing differences effectively.
  • Proven ability to identify, prioritize & resolve key project and partner issues, work with and harmonize demands from multiple “customers”, both internally and with partners
  • Demonstrated ability to combine attention to detail with big picture perspective, operationalizing via excellence in project management and effectively managing multiple projects/priorities.
  • Must be fluent in English (written and spoken)
  • International Alliance Management experience is a plus.
  • Demonstrated competence in written and verbal communication - Must be proficient in the use of MS Power Point, Excel & Word

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