* Fulcrum requires all employees to be fully vaccinated against COVID-19.  This requirement is a condition of employment at Fulcrum, and it applies regardless of whether or not the position is located onsite at Fulcrum’s headquarters in Cambridge, MA.  If you are unable to receive the vaccine due to a serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

Company Overview 

Fulcrum Therapeutics is a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases in areas of high unmet medical need. The company’s proprietary product engine, FulcrumSeekTM, identifies drug targets that can modulate gene expression to treat the known root cause of gene mis-expression. Fulcrum has advanced FTX-6058, an oral fetal hemoglobin (HbF)-inducer small molecule designed to increase expression of fetal hemoglobin, for the treatment of sickle cell disease and non-sickle cell disease hemoglobinopathies (including beta-thalassemia) into early proof-of-concept trials.  In addition, the company has recently completed a Phase 2 trial of losmapimod for the treatment of facioscapulohumeral muscular dystrophy (FSHD) and has demonstrated disease-modifying potential of losmapimod in this disease.


The Vice President Program Strategy Lead , Hematology, will lead a multi-functional development team from proof of concept trials through marketing authorizations.  This leader will focus primarily on FTX-6058 (Hematology), about which Fulcrum has recently reported Phase 1 proof-of-mechanism and proof-of-biology results.  The Phase 1 healthy-volunteer study demonstrated best-in-class potential as an oral HbF inducer.  This program has the potential to move quickly through development to marketing applications.  Fulcrum aims to deliver this drug as quickly as possible to people living with sickle cell disease and other beta-globinopathies.  This leader will be responsible for the strategy and execution of that strategy that will bring this drug forward through the next phases of development, including global regulatory interactions, for sickle cell disease as well as other indications.  This role will report directly to the Chief Operating Officer, COO.  Given the high profile of this program, this leader will interact regularly with the R&D leadership team, the executive team, and the board of directors within the company and with key external stakeholders ranging from individual people living with these hematologic diseases to payors.


  • Drive strategy for the program to ensure rapid and efficient development and new drug applications, including late-phase development (such as clinical trials) and new drug launch preparations
  • Work collaboratively with R&D and Commercial leaders in developing strategy and execution plans
  • Through the team’s program manager and each functional representative, ensure that the strategy is executed on time and on budget
  • Anticipate and proactively mitigate risks to the program in conjunction with program management
  • Build and maintain a high-functioning, multi-disciplined and cross-functional program team
  • Ensure the team operates with the highest scientific and medical integrity
  • Through functional members, develop a set of external expert advisers that will collaborate on strategy and execution.
  • Create a nurturing creative environment on the team that fosters collaboration
  • Represent the team at internal governance meetings, with the support of team members

Represent the program and Fulcrum externally with interactions with health authorities/regulators, scientists, clinicians, patients, and patient advocacy events


  • An advanced degree, such as PhD, MD, DO, or PharmD,
  • Experience in rare diseases is a preferred.
  • 10+ years of biopharmaceuticals experience, preferably in R&D and preferably in either clinical development or program leadership
  • Early and late development experience is preferred
  • Proven success in a fast paced, entrepreneurial, smaller company environment is highly desired.
  • Previous experience building teams and leading teams.
  • Prior experience of managing complex budgets.
  • Demonstrated ability to work in ambiguous environment and drive towards results.
  • Strong interpersonal skills including developing relationships at all levels in an organization and external to the organization to influence business objectives.
  • Commitment to working collaboratively and to building team and company culture.
  • Analytical, strategic thinker with good problem-solving skills.
  • Articulate and persuasive in both scientific and business forums.
  • Excellent written and verbal communication skills.

Location and Travel:

  • This is a Boston-area based position (Fulcrum’s office is in Cambridge), with expectations that this leader will work flexibly yet regularly in the office.
  • Anticipate 10-20% travel as travel expands once again

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