* Fulcrum requires all employees to be fully vaccinated against COVID-19.  This requirement is a condition of employment at Fulcrum, and it applies regardless of whether or not the position is located onsite at Fulcrum’s headquarters in Cambridge, MA.  If you are unable to receive the vaccine due to a serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

Company Overview 

Fulcrum Therapeutics is a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases in areas of high unmet medical need. The company’s proprietary product engine, FulcrumSeekTM, identifies drug targets that can modulate gene expression to treat the known root cause of gene mis-expression. Fulcrum has advanced FTX-6058, an oral fetal hemoglobin (HbF)-inducer small molecule designed to increase expression of fetal hemoglobin, for the treatment of sickle cell disease and non-sickle cell disease hemoglobinopathies (including beta-thalassemia) into early proof-of-concept trials.  In addition, the company has recently completed a Phase 2 trial of losmapimod for the treatment of facioscapulohumeral muscular dystrophy (FSHD) and has demonstrated disease-modifying potential of losmapimod in this disease.

Description

The Vice President Program Strategy Lead , Hematology, will lead a multi-functional development team from proof of concept trials through marketing authorizations.  This leader will focus primarily on FTX-6058 (Hematology), about which Fulcrum has recently reported Phase 1 proof-of-mechanism and proof-of-biology results.  The Phase 1 healthy-volunteer study demonstrated best-in-class potential as an oral HbF inducer.  This program has the potential to move quickly through development to marketing applications.  Fulcrum aims to deliver this drug as quickly as possible to people living with sickle cell disease and other beta-globinopathies.  This leader will be responsible for the strategy and execution of that strategy that will bring this drug forward through the next phases of development, including global regulatory interactions, for sickle cell disease as well as other indications.  This role will report directly to the Chief Operating Officer, COO.  Given the high profile of this program, this leader will interact regularly with the R&D leadership team, the executive team, and the board of directors within the company and with key external stakeholders ranging from individual people living with these hematologic diseases to payors.

Responsibilities

  • Drive strategy for the program to ensure rapid and efficient development and new drug applications, including late-phase development (such as clinical trials) and new drug launch preparations
  • Work collaboratively with R&D and Commercial leaders in developing strategy and execution plans
  • Through the team’s program manager and each functional representative, ensure that the strategy is executed on time and on budget
  • Anticipate and proactively mitigate risks to the program in conjunction with program management
  • Build and maintain a high-functioning, multi-disciplined and cross-functional program team
  • Ensure the team operates with the highest scientific and medical integrity
  • Through functional members, develop a set of external expert advisers that will collaborate on strategy and execution.
  • Create a nurturing creative environment on the team that fosters collaboration
  • Represent the team at internal governance meetings, with the support of team members

Represent the program and Fulcrum externally with interactions with health authorities/regulators, scientists, clinicians, patients, and patient advocacy events

Qualifications            

  • An advanced degree, such as PhD, MD, DO, or PharmD,
  • Experience in rare diseases is a preferred.
  • 10+ years of biopharmaceuticals experience, preferably in R&D and preferably in either clinical development or program leadership
  • Early and late development experience is preferred
  • Proven success in a fast paced, entrepreneurial, smaller company environment is highly desired.
  • Previous experience building teams and leading teams.
  • Prior experience of managing complex budgets.
  • Demonstrated ability to work in ambiguous environment and drive towards results.
  • Strong interpersonal skills including developing relationships at all levels in an organization and external to the organization to influence business objectives.
  • Commitment to working collaboratively and to building team and company culture.
  • Analytical, strategic thinker with good problem-solving skills.
  • Articulate and persuasive in both scientific and business forums.
  • Excellent written and verbal communication skills.

Location and Travel:

  • This is a Boston-area based position (Fulcrum’s office is in Cambridge), with expectations that this leader will work flexibly yet regularly in the office.
  • Anticipate 10-20% travel as travel expands once again

Apply for this Job

* Required
resume chosen  
Dropbox
(File types: pdf, doc, docx, txt, rtf)
Cancel
cover_letter chosen  
Dropbox
(File types: pdf, doc, docx, txt, rtf)
Cancel

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Fulcrum Therapeutics’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Form CC-305

OMB Control Number 1250-0005

Expires 05/31/2023

Voluntary Self-Identification of Disability

Why are you being asked to complete this form?

We are a federal contractor or subcontractor required by law to provide equal employment opportunity to qualified people with disabilities. We are also required to measure our progress toward having at least 7% of our workforce be individuals with disabilities. To do this, we must ask applicants and employees if they have a disability or have ever had a disability. Because a person may become disabled at any time, we ask all of our employees to update their information at least every five years.

Identifying yourself as an individual with a disability is voluntary, and we hope that you will choose to do so. Your answer will be maintained confidentially and not be seen by selecting officials or anyone else involved in making personnel decisions. Completing the form will not negatively impact you in any way, regardless of whether you have self-identified in the past. For more information about this form or the equal employment obligations of federal contractors under Section 503 of the Rehabilitation Act, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

You are considered to have a disability if you have a physical or mental impairment or medical condition that substantially limits a major life activity, or if you have a history or record of such an impairment or medical condition.

Disabilities include, but are not limited to:

  • Autism
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, or HIV/AIDS
  • Blind or low vision
  • Cancer
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or hard of hearing
  • Depression or anxiety
  • Diabetes
  • Epilepsy
  • Gastrointestinal disorders, for example, Crohn's Disease, or irritable bowel syndrome
  • Intellectual disability
  • Missing limbs or partially missing limbs
  • Nervous system condition for example, migraine headaches, Parkinson’s disease, or Multiple sclerosis (MS)
  • Psychiatric condition, for example, bipolar disorder, schizophrenia, PTSD, or major depression

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.

Please reach out to our support team via our help center.