* Fulcrum requires all employees to be fully vaccinated against COVID-19.  This requirement is a condition of employment at Fulcrum, and it applies regardless of whether or not the position is located onsite at Fulcrum’s headquarters in Cambridge, MA.  If you are unable to receive the vaccine due to a serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

 

Company Overview

Fulcrum Therapeutics is a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases in areas of high unmet medical need. Fulcrum’s two lead programs in clinical development are losmapimod, a small molecule for the treatment of facioscapulohumeral muscular dystrophy (FSHD) and FTX-6058, a small molecule designed to increase expression of fetal hemoglobin for the treatment of sickle cell disease and other hemoglobinopathies, including beta-thalassemia. The company’s proprietary product engine, FulcrumSeekTM, identifies drug targets that can modulate gene expression to treat the known root cause of gene mis-expression.

Description

As a member of the pharmacology team at Fulcrum Therapeutics, this role will be responsible for the design and execution of mechanistic in vivo and ex-vivo pharmacology research projects in research areas such as genetically defined hematological, musculoskeletal, and other rare disorders. The candidate will be part of a multi-disciplinary team to conduct experiments aimed at building relationships between in vitro cellular assays and in vivo/ ex-vivo PK/PD, target engagement, and efficacy of potential drug candidates to drive drug discovery. We seek an innovative scientist who is looking to be part of a dynamic team, open to new challenges and excited to have a direct impact on the discovery and development of novel therapies for patients living with rare diseases.

Responsibilities

  • Responsible for independently conducting in vivo studies with rodents in accordance with IACUC requirements.
  • Contribute to study designs, planning and performing in vivo studies related to PK/PD and efficacy studies from early exploratory to IND stage.
  • Provide analysis and interpretation of data with clear communication in cross-functional team meetings.
  • Perform routine rodent handling and dosing independently by various routes (e.g., oral gavage, IP, IV, SC, IM)
  • Perform blood draws, necropsies, and process ex vivo samples.
  • Conduct assays for ex vivo target engagement and biomarker analysis from tissue and blood samples to understand the mechanism of action of various therapeutic agents.
  • Ability to conduct in vitro assays, gene expression analysis, protein analysis and general molecular biology techniques is a plus.
  • Demonstrate independent thought/creativity in science with excellent collaboration and communication across functional disciplines, multitasking skills and able to present work formally to scientific research committees.
  • Maintain accurate, timely and complete electronic laboratory notebook entries.

Qualifications

  • BS or MS with relevant experience in areas related to Cell Biology, Molecular Biology and/or Pharmacology in an academic or industry setting.
  • Proven track record of performing in vivo experiments in rodents, including handling, dosing and necropsy.
  • Experience managing CROs desired.
  • Hands-on experience with a range of in vitro/ ex vivo techniques (such as RNA/DNA extraction, qPCR, ELISA, protein analysis via Western blot, WES, and/or MSD) is desirable.
  • Experience running flow, ICC, FISH, and/or IHC imaging assays is a plus.
  • Demonstrated ability to execute experiments, analyze data and report conclusions.
  • Passionate about contributing to the team in a diverse and inclusive environment every day, in- and outside the lab.
  • Ability to thrive in a highly collaborative, fast-paces, team-oriented environment with diverse disciplines.
  • Outstanding interpersonal and communication (written and verbal) skills; demonstrates calm, professional, diplomatic, and positive behaviors.

 

Apply for this Job

* Required
resume chosen  
Dropbox
(File types: pdf, doc, docx, txt, rtf)
Cancel
cover_letter chosen  
Dropbox
(File types: pdf, doc, docx, txt, rtf)
Cancel

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Fulcrum Therapeutics’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Form CC-305

OMB Control Number 1250-0005

Expires 05/31/2023

Voluntary Self-Identification of Disability

Why are you being asked to complete this form?

We are a federal contractor or subcontractor required by law to provide equal employment opportunity to qualified people with disabilities. We are also required to measure our progress toward having at least 7% of our workforce be individuals with disabilities. To do this, we must ask applicants and employees if they have a disability or have ever had a disability. Because a person may become disabled at any time, we ask all of our employees to update their information at least every five years.

Identifying yourself as an individual with a disability is voluntary, and we hope that you will choose to do so. Your answer will be maintained confidentially and not be seen by selecting officials or anyone else involved in making personnel decisions. Completing the form will not negatively impact you in any way, regardless of whether you have self-identified in the past. For more information about this form or the equal employment obligations of federal contractors under Section 503 of the Rehabilitation Act, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

You are considered to have a disability if you have a physical or mental impairment or medical condition that substantially limits a major life activity, or if you have a history or record of such an impairment or medical condition.

Disabilities include, but are not limited to:

  • Autism
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, or HIV/AIDS
  • Blind or low vision
  • Cancer
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or hard of hearing
  • Depression or anxiety
  • Diabetes
  • Epilepsy
  • Gastrointestinal disorders, for example, Crohn's Disease, or irritable bowel syndrome
  • Intellectual disability
  • Missing limbs or partially missing limbs
  • Nervous system condition for example, migraine headaches, Parkinson’s disease, or Multiple sclerosis (MS)
  • Psychiatric condition, for example, bipolar disorder, schizophrenia, PTSD, or major depression

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.

Please reach out to our support team via our help center.