The Company

Dyno Therapeutics is reshaping the gene therapy landscape through AI-powered vectors. Through the application of our transformative technologies and strategic partnerships with leaders in gene therapy, we believe a future with life changing gene therapies for millions of people is within reach.

Our team includes world-class molecular and synthetic biologists, protein engineers and gene therapy scientists working alongside software engineers, data scientists, and machine learning experts to transform the landscape of available gene therapy capsids. Dyno has been named the 2021 NEVY Emerging Company of the Year, an Endpoints 11 Company and one of America’s Best Startups by Forbes in 2022 and 2023!

The Role

Associate Director - Vector Production. A strategic and results-driven leader who will play a pivotal role in advancing Dyno’s mission by optimizing and scaling AAV production processes.

How You Will Contribute

As Associate Director - Vector Production, you will be tasked with executing pooled library productions for Dyno’s NHP studies. Your expertise in vector production and team management will drive the achievement of ambitious production goals to support our groundbreaking gene therapy work. You will ensure the production of high-quality AAV vectors that meet strict criteria and enable our studies to advance.

Responsibilities:

Oversee, plan, and execute end-to-end AAV vector production processes at relevant scales, ensuring alignment with organizational goals and timelines, for novel capsids designed by Dyno’s AAV platform.
Utilize run/batch summaries to synthesize production outcomes and contextualize process performance.
Develop a strategy to ensure Dyno’s vector production capabilities can meet the demand of the organization’s broader capsid engineering strategy.
Lead and develop a high-performing team, including managing a small team of direct reports.
Work collaboratively to drive process optimization across upstream (e.g., suspension culture or adherent bioreactors) and downstream (e.g., depth filtration, TFF, FPLC) processes.
Collaborate with cross-functional teams to ensure seamless integration of production workflows with broader Dyno goals.

Who you are

Results-driven and steadfast
Unafraid to ask hard questions
Curious and quick to adapt
Balances urgency with strategic focus
Collaborative across diverse stakeholders
Consistent and transparent partner
Team-oriented and inclusive
Mindful and detail-oriented
Affinity for opportunities at the intersection of data science and biology

Basic qualifications

MS or Ph.D in bioprocessing, chemical engineering, vector biology, or biological sciences.
- MS with a minimum of 8-10+ years experience in the biotechnology or pharma industry OR PhD with 5+ years of relevant experience in a AAV manufacturing setting.
Experience running end-to-end vector production processes at scale, either in suspension culture at ≥50 L or medium/large-scale adherent bioreactors (e.g., iCellis, Univercells scale-x carbo, or similar).
Proven expertise managing both upstream (stir-tanks/rockers if in suspension) and downstream (depth filtration, TFF, FPLC, fill/finish) processes of AAV production.
Well-developed background in process optimization.
Experience leading a team of at least three direct reports.

Preferred qualifications

Experience in AAV vector production quality control, either through direct involvement or in-depth interaction.
Experience in suspension production if prior experience is primarily in adherent culture.

Fraud Alert: Please be aware of recruitment scams targeting job seekers. Dyno Therapeutics will never make an offer of employment without conducting a formal interview process, nor will we ask for personal information such as financial details over email. Official communication will only come from an @dynotx.com email address. If you are contacted by someone claiming to represent Dyno Therapeutics from any other domain, please report it as spam and report the communication to us at jobs@dynotx.com.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Job Type: Full-time

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