Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine.

The Opportunity

In anticipation of the Company’s growth plans, Denali Therapeutics is seeking to recruit a Principal Scientist (Pathology).  The Pathologist will provide scientific guidance and leadership in the preclinical safety de-risking of small and large molecule therapeutics, and work in close collaboration with colleagues in Research and Development.


  • Provide pathology evaluation for discovery, investigative and regulatory toxicology studies, as well as efficacy studies
  • Provide pathology expertise and guidance to scientific staff in Safety Assessment, Translational Sciences and Research
  • Pathology peer review of toxicology studies
  • Integrate and interpret pathology findings
  • Develop optimal safety de-risking strategies in partnership with toxicologists
  • Opportunity to function as Project Toxicologist
  • Lead investigative efforts into mechanisms of toxicity, as needed
  • Advise on Immunohistochemistry protocol development and interpretation


  • Doctor of Veterinary Medicine (DVM or equivalent)
  • Board Certification in Veterinary Anatomic Pathology
  • At least 5 years of drug development experience  
  • Experience with small molecules and biologics desirable
  • Strong scientific background and acumen
  • Excellent critical thinking skills
  • Ability to work effectively and collaboratively on cross-functional projects teams, and demonstrated can-do attitude
  • Ability to work in a fast-paced environment
  • Excellent oral, presentation, and written communication skills


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