Company Description

Detect’s mission is to empower individuals to have greater ownership of their health with rapid, low-cost home and point-of-care diagnostics. We build breakthrough technology at the intersection of software, hardware, chemistry, and biology to make accurate diagnostics accessible at the point of need. Our ultimate goal is to apply this technology to lower costs, improve patient outcomes, and improve doctor experience by enabling earlier diagnosis and access to treatment.

Detect is a well-funded, rapidly growing health-tech company founded by award-winning scientist and highly successful serial entrepreneur, Dr. Jonathan Rothberg. Detect benefits from being a 4Catalyzer company, an incubator of biotech and med device companies who have collectively raised over $2 billion in funding. 

Joining Detect is the opportunity to redesign the future of healthcare through the power of technology. Embark on a journey with us to maximize global impact, motivated by the idea that our products will change the lives of millions along with the people you love. 

Job Description

Detect is offering an exciting opportunity to join our Research and Development Team, located at Detect’s main campus in Guilford, CT. We are seeking a highly skilled and experienced Principal Scientist, Biomanufacturing to develop and implement strategies for manufacturing shelf-stable biological reagents and formulated assay mixes to be packaged in diagnostic test kits. This is a leadership role that requires strong project management skills, technical expertise, and the ability to work cross-functionally and collaboratively with technical, operations, quality, regulatory, and commercial teams. 

As a Principal Scientist, Biomanufacturing, you’ll have the unique opportunity to:

  • Develop and maintain a comprehensive strategic plan for producing shelf-stable diagnostic test kit reagents, striving for continuous improvement on scale, quality, and cost
  • Lead a lean and efficient cross-functional project team with the following responsibilities:
    • Source and/or produce in-house raw material reagents (including proteins, small molecules, and other biomolecules) to support the development of high-quality in vitro diagnostic assays
    • Establish and maintain an internal facility for reagent production and shelf-stable formulations
    • Develop a formulation process and apply it to manufacture shelf-stable reagents at a pilot scale for use in commercially available diagnostic test kits
    • Ensure the stability and quality of all raw material reagents and shelf-stable formulations in the finished product
  • Direct the development and validation of biomanufacturing processes that are highly scalable and transferable for internal or external manufacturing
  • Support the development and transfer of robust analytical methods and a control strategy to ensure that reagents consistently meet high quality standards
  • Champion compliance with applicable regulations and requirements, including GMP, ISO, and FDA guidelines, and ensure strong documentation processes
  • Act as a subject matter expert, both internally and with external partners, to resolve issues, meet production goals and timelines, and mitigate risks in our manufacturing processes
  • Communicate effectively with all levels of the organization, providing regular updates on production progress, challenges, and identifying opportunities for technical innovation in the biomanufacturing space


Successful candidates will possess diversified knowledge of the principles & practices in broad areas, with technical depth in the areas indicated below. They will be effective at framing large-scale problems and balancing scientific rigor with intuition to most efficiently arrive at technical recommendations. We are looking for candidates that are self-directed – able to both work with complete independence but also develop strategic plans to organize collaborative work with others and the team they lead. Candidates will thrive if they have strong time management and scientific leadership skills. Above all, successful candidates will aspire towards a high level of personal productivity, be driven towards scientific excellence, and demonstrate a desire for continuous self-improvement and development.

Baseline skills/experiences/attributes:

  • Bachelor's or Master's degree in Biology, Chemistry, Biochemistry, or related field. A Ph.D. in a relevant field is a plus
  • 10+ years of experience in biomanufacturing, or 7+ years with a Ph.D., with a focus on one or more of the following areas: process chemistry, fermentation, lyophilization, and production of shelf-stable reagents for use in commercially available in vitro diagnostic assays
  • Experience with commercialization of molecular diagnostic products and/or reagents
  • Extensive experience with the development of robust analytical methods for use in product development and quality control
  • Excellent problem-solving and analytical skills, with the ability to identify and implement solutions to complex problems. Familiarity with data analysis tools for statistical analysis is a plus
  • Knowledge of relevant regulatory requirements and best practices, including GMP, ISO, and FDA regulations relevant for production of diagnostic products
  • Experience reviewing and/or authoring master batch records, validation reports and other manufacturing documentation
  • Experience in technology transfer with biologic-based contract manufacturers, including translating product and process requirements into specifications
  • Strong leadership and management skills, with experience leading and managing lean and efficient teams
  • Strong communication and interpersonal skills, with the ability to collaborate effectively with cross-functional teams
  • Experience working with information management systems or related PLM software

Ideally, you also have these skills/experiences/attributes (but it’s ok if you don’t!):

  • Experience working in dynamic start-up environments
  • Demonstrated ability to develop and implement GMP-compliant manufacturing processes and quality systems
  • Experience with commercialization of molecular diagnostic products and reagents specific to isothermal amplification tests and applications
  • Experience with protein fermentation, production, and/or commercialization
  • Experience with regulatory requirements for the production of biological reagents for in vitro diagnostic assays
  • Experience with pilot-scale QC of formulated master mixes and freeze-dried assays
  • Experience with developing and implementing automation processes for biomanufacturing

You Deeply Identify with and demonstrate Detect’s Core Values:

  • Put people first. Our colleagues and our customers come first. We respect each other and celebrate our diversity. We take joy in each other’s success, and succeed or fail as a team
  • Eye of the owner. We have an ownership mindset and take responsibility for all of our decisions. No problem is someone else's problem. We are frugal and use company resources as if they were our own
  • No genius without grit. As innovators, we fail often but fast. We are tenacious. We push through adversity and keep getting up. We are problem solvers and always find a way
  • Err on the side of doing. We are scrappy and biased toward action — everyone is an individual contributor. We allow intuition to guide us when we have imperfect information
  • Move fast by working smart. We are inventors. We focus, plan, pursue, and adjust to make big things happen in a fraction of the time others can. We disagree and commit
  • Always be frank. We celebrate openness and diversity of opinion. We are transparent and candid but compassionate in our feedback, and are always honest to ourselves and our customers

Additional Information

We offer great perks: 

  • Fully covered medical insurance plan, and dental & vision coverage - as a health-tech company, we place great worth on our teams’ well-being
  • Competitive salaried compensation - we value our employees and show it 
  • Equity - we want every employee to be a stakeholder
  • Pre-tax commuter benefits - we make your commute more reasonable 
  • Free onsite meals + kitchen stocked with snacks
  • 401k plan - we facilitate your retirement goals
  • Beautiful office near the ocean-front in historic Guilford, Connecticut
  • The opportunity to build a revolutionary healthcare product and save millions of lives! 

For this role, we provide visa assistance for qualified candidates. 

Detect does not accept agency resumes.

Detect is an E-Verify and equal opportunity employer regardless of race, color, ancestry, religion, gender, national origin, sexual orientation, age, citizenship, marital status, disability or Veteran status. All your information will be kept confidential according to EEO guidelines.

Apply for this Job

* Required
resume chosen  
(File types: pdf, doc, docx, txt, rtf)
cover_letter chosen  
(File types: pdf, doc, docx, txt, rtf)

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Detect’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Voluntary Self-Identification of Disability

Form CC-305
Page 1 of 1
OMB Control Number 1250-0005
Expires 04/30/2026

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

  • Alcohol or other substance use disorder (not currently using drugs illegally)
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
  • Blind or low vision
  • Cancer (past or present)
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or serious difficulty hearing
  • Diabetes
  • Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
  • Epilepsy or other seizure disorder
  • Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
  • Intellectual or developmental disability
  • Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
  • Missing limbs or partially missing limbs
  • Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
  • Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
  • Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
  • Partial or complete paralysis (any cause)
  • Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
  • Short stature (dwarfism)
  • Traumatic brain injury

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.

Please reach out to our support team via our help center.
Please complete the reCAPTCHA above.