The Company

Cygnal Therapeutics is a privately held, early-stage biotechnology company pioneering the field of Exoneural Biology – the neural regulation of cancer, immunity, and regeneration. Cygnal is developing drugs to manipulate Exoneural Biology for the treatment of cancer, immunological diseases, and regenerative processes. Cygnal Therapeutics was founded by Flagship Pioneering, in the VentureLabs innovation foundry, which has created over 50 groundbreaking companies that are developing novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability.

The Position

Cygnal is seeking a Postdoctoral/Associate Scientist to help us advance the science of Exoneural Biology by developing novel tissue engineering systems to study nerve- endometrial tissue interactions. We are searching for enthusiastic, innovative, and highly motivated individuals who are comfortable working in a fast-paced entrepreneurial environment.  The candidate will be responsible for study design, experimentation, and data analysis. The position will require creativity, resourcefulness, and adaptability. The ideal candidate must be goal oriented with strong analytical and problem-solving skills and possesses the ability to work independently and collaborate with others effectively.


  • Create novel Exoneural co-culture systems that incorporate human iPSC derived sensory neurons and cells of endometrial tissues, including epithelial cells and macrophages by adapting protocols developed by external collaborators and at Cygnal.
  • Work closely with a world-leading tissue engineering academic laboratory (Linda Griffith/ MIT) to develop novel 3D culture systems incorporating multiple cell types with spatial and mechanical properties relevant to human endometrial tissue.
  • Establish functional read-outs in these co-culture systems including a compendium of molecular, cellular, and macroscopic phenotypic behaviors including neuronal sensory threshold; dynamics of invasion / nerve growth; proliferation and inflammatory status of immune and tissue cells; protein and gene expression (via flow cytometry, RNA-seq, targeted proteomics).
  • Design & execute experiments, interpret data & validate results, identify & solve problems. Communicate data both internally and to external collaborators.

Skills & Abilities

  • Good understanding of cellular and molecular biology principles, with strong background in neuroscience and/or stem cell biology desired.
  • Strong experimental skills including tissue culture is a must-have. Prior experience in culturing and differentiating human induced pluripotent stem cells (iPSCs) is highly preferred.
  • Motivated, curious and adaptable with excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner.
  • Confident, execution focused, team oriented, with an ability to thrive in an entrepreneurial environment.

Education & Experience

  • PhD in Biology, Biological Engineering or relevant field, prior experience in human induced pluripotent stem cell culture and differentiation preferred.
Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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