Cygnal, a new biology platform company, was founded by Flagship Pioneering to pioneer the field of exoneural biology – the impact of the peripheral nervous system on cancer, the immune system, metabolism, and regeneration. The company is applying cutting-edge neuroscience to elucidate novel therapies to treat cancer progression and metastasis, autoimmune conditions, inflammation, and other diseases.

Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $30 billion in aggregate value. To date, Flagship is backed by >$3 billion of aggregate capital commitments, of which over $1.4 billion has been deployed toward the founding and growth of its pioneering companies alongside >$10 billion of follow-on investments from other institutions. The current Flagship ecosystem includes Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Seres Therapeutics (NASDAQ: MCRB), and Syros Pharmaceuticals (NASDAQ: SYRS).


The ExoNeuro team is at the core of drug discovery, tool and technology development and is responsible for collaborating with other disease area units to identify novel targets, develop modulators and investigate biological mechanistic insights. The successful candidate will be leading projects and processes related to modeling of human disorders that rely on interactions between nervous system and non-neuronal cells, primarily in the context of oncology and inflammation. The candidate will be responsible for the direction and execution of projects, including novel assay development, in vitro proof-of concept, designing in vivo translational studies, and aligning the scientific plan with corporate objectives. This position will require creativity, resourcefulness, adaptability, and the ability to work across line functions and disease areas with high degree of collaboration.


  • Design experimental plans for pathway validation and target identification, including in vitro and in vivo assay development in collaboration with line function teams.
  • Execute experiments, interpret and validate results, and communicate data to scientific team and executive management.
  • Manage external research relationships with academic and commercial partners.
  • The candidate must be independent, goal oriented, and able to efficiently lead a cross functional team and complete multiple projects in parallel.


  • PhD or equivalent in the biological sciences, bioengineering, or related fields
  • 5+ years of relevant laboratory experience, in academic, pharmaceutical or biotechnology settings.
  • Deep knowledge of nervous system biology
  • Strong experimental skills in design and execution of in vitro and in vivo assays and disease modeling
  • Excellent communication and presentation skills to convey scientific and technical information effectively
  • Experience with peripheral nervous system and its interaction with non-nervous system biology in the context of disease is a plus
  • Experience in target validation, assay development and drug discovery is a plus


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