Company Summary:
Cygnal, a new biology platform company, was founded by Flagship Pioneering to pioneer the field of exoneural biology – the impact of the peripheral nervous system on cancer, the immune system, metabolism, and regeneration. The company is applying cutting-edge neuroscience to elucidate novel therapies to treat cancer progression and metastasis, autoimmune conditions, inflammation, and other diseases.

Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $30 billion in aggregate value. To date, Flagship is backed by >$3 billion of aggregate capital commitments, of which over $1.4 billion has been deployed toward the founding and growth of its pioneering companies alongside >$10 billion of follow-on investments from other institutions. The current Flagship ecosystem includes Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Seres Therapeutics (NASDAQ: MCRB), and Syros Pharmaceuticals (NASDAQ: SYRS).

Position Summary:
Cygnal Therapeutics is seeking a highly motivated and innovative in vitro scientist/biochemist to join its team of experienced drug hunters to identify and develop large biologic molecules for therapeutic intervention. The successful candidate will report to the VP Biologics Drug Discovery and be part of a cross-functional team that collaboratively develops therapeutic monoclonal antibodies and recombinant proteins. He or she will work closely with our target identification and validation team, our Bioinformatics team and our in vivo pharmacology team, in a highly collaborative and high-pace environment. The successful candidate should be a self-motivated individual with a drive to advance therapeutic Biologics molecules in a timely fashion. The successful candidate should be able to independently design, process and interpret scientific experiments and data and inform key stakeholders of their findings in a clear and concise fashion.
Key Responsibilities:
  • Coordinate the cloning, expression and purification of recombinant proteins and monoclonal antibodies
  • Develop immune-based (ELISA) assays, in vitro binding assays (e.g. FRET) and ligand blocking assays that are suitable for the identification of novel therapeutic monoclonal antibodies
  • Generate cell lines (by Lentiviral infections, transfections etc) and develop cell-based assays suitable for monoclonal antibody identification (i.e. reporter assays, cytokine secretion assays, as well as cell binding assays of monoclonal antibodies and protein ligands)
  • Conduct cell profiling studies (secreted proteins/cytokines, RNA profiling)
  • Deploy the generated cell-based and biochemical assays for the testing of a subset of monoclonal antibodies of interest in a screening campaign
  • Determine the binding characteristics of purified recombinant proteins and identified monoclonal antibodies of interest (e.g. Octet, Biacore)
  • Develop target engagement assays, anti-IgG and anti-Idiotype assays, as well as anti-drug assays
Minimum Qualifications:
  • Ph.D. or MSc in biochemistry or relevant biological science with 2+ years (PhD) or 5+ years (MSc) of experience in the biotechnology and/or pharmaceutical industry, identifying and developing Biologics for therapeutic intervention
  • Expertise in biochemistry, cell biology and molecular biology
  • Thorough understanding of the drug discovery process
  • Experience with the development of biochemical and cell-based assays
  • Experience with the identification and optimization of monoclonal antibodies
  • Experience with outsourcing of research activities to contract research organizations (CROs)
  • Be a self-motivated, well-organized individual, capable of working independently as well as in a collaborative/group environment
  • Possess strong oral and written communication skills
Preferred Qualifications:
  • Drug discovery experience in the field of oncology, immuno-oncology or neuroscience
  • Experience with protein purification and analytical techniques (HPLC, CD, SEC-MALS etc)
  • Experience with tissue culture, cell line generation and flow cytometry
  • Experience with multiple different antibody identification platforms
  • Demonstrated contributions to therapeutic monoclonal antibody development
  • Excellent scientific track record of high impact, peer-reviewed publications and patents
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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