The Company
Cygnal, a new biology platform company, was founded by Flagship Pioneering to pioneer the field of exoneural biology – the impact of the peripheral nervous system on cancer, the immune system, metabolism, and regeneration. The company is applying cutting-edge neuroscience to elucidate novel therapies to treat cancer progression and metastasis, autoimmune conditions, inflammation, and other diseases.

Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $30 billion in aggregate value. To date, Flagship is backed by >$3 billion of aggregate capital commitments, of which over $1.4 billion has been deployed toward the founding and growth of its pioneering companies alongside >$10 billion of follow-on investments from other institutions. The current Flagship ecosystem includes Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Seres Therapeutics (NASDAQ: MCRB), and Syros Pharmaceuticals (NASDAQ: SYRS).

Position Summary:
Cygnal Therapeutics is seeking a Scientist with a strong background within in vivo preclinical pharmacology and animal model development to play a significant role in designing and executing in vivo studies. The Scientist will play a vital role in the company’s efforts to advance the science of Exoneural Biology. The candidate must be independent, goal oriented, have excellent communication skills and be willing to work in a highly dynamic and fast-paced entrepreneurial environment.
Basic Qualifications:
  • M.S. with 5+ years (Sr. Associate, Associate Scientist), or Ph.D. (Associate Scientist, Scientist) with 2+ years in pharmacology, animal science, immunology, neurobiology or related discipline.
  • Expertise in designing and independently executing broad sets of in vivo experiments required to validate or identify novel targets for cancer and immune disease.
  • Assist with training of new hires
  • Execute, troubleshoot, and optimize in vivo study protocols, IACUC protocols, internal SOP, and survey scientific literature to inform the development of additional in vivo assays.
  • Strong rodent animal handling skills and hands-on in vivo pharmacology skills, including dosing (IV, SC, IP, and PO), cell line work, preparation of test compounds, dosing, anesthesia, necropsy, blood and tissue collection for PK and PD biomarker analysis
  • Familiar with immune-oncology models, inflammatory disease models
  • Highly skilled in small animal surgery, such as orthotopic implantation of tumor cells into various organs of rodents
  • Adaptive and a quick learner, Efficient in multi-tasking and trouble-shooting, highly organized and good record keeping, excellent interpersonal and communication skills to excel in the teamwork environment. The ability and strong desire to "do what it takes to make things happen” attitude. Demonstrate the ability to work independently.
  • Ability to prioritize responsibilities to meet project deadlines and flexibility to react quickly to changing research needs
Preferred Qualifications:
  • Small rodents microsurgery experience: sciatic nerve crush, optic nerve crush, spinal cord injury, in-utero electroporation
  • Necropsy experience: DRG dissection, sympathetic chain ganglia dissection, enteric nervous system dissection
  • Viral delivery experience: AAV intracranial injection
  • Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner.
  • Eager to work with highly-skilled and dynamic teams in a fast-paced, entrepreneurial and technical setting.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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