Cygnal, a new biology platform company, was founded by Flagship Pioneering to pioneer the field of exoneural biology – the impact of the peripheral nervous system on cancer, the immune system, metabolism, and regeneration. The company is applying cutting-edge neuroscience to elucidate novel therapies to treat cancer progression and metastasis, autoimmune conditions, inflammation, and other diseases.

Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $30 billion in aggregate value. To date, Flagship is backed by >$3 billion of aggregate capital commitments, of which over $1.4 billion has been deployed toward the founding and growth of its pioneering companies alongside >$10 billion of follow-on investments from other institutions. The current Flagship ecosystem includes Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Seres Therapeutics (NASDAQ: MCRB), and Syros Pharmaceuticals (NASDAQ: SYRS).

Cygnal Therapeutics is seeking a highly motivated and experienced medicinal chemist to join our team of drug hunters to drive projects from lead generation to clinical candidate selection. The successful candidate will report to the SVP Small Molecules Drug Discovery and be self-starter who thrives in a highly collaborative and fast paced environment.
  • Apply your drug hunting expertise leading teams to plan and execute lead generation and optimization campaigns.
  • Work closely and collaboratively in a multi-disciplinary team of computational chemists, biophysicists, cell and molecular biologists, pharmacologists, and DMPK specialists.
  • Oversee all aspects of compound performance through selection of development candidate and communicate effectively to your discovery partners and senior leadership.
  • Prioritize medicinal chemistry activities and resources to ensure timeline adherence and project alignment with company goals.
  • Contribute to secure a robust small molecule patent estate.
  • Manage external resources at CROs as well as direct reports on-site
  • Proactively identify sources of inefficiency, new opportunities and collaborations and propose actions.
  • Ph.D. in chemistry with an emphasis on synthetic organic chemistry, synthetic methodology or a related field
  • 10+ years of relevant biotech and/or pharmaceutical industry experience in medicinal chemistry
  • Led and participated in the delivery of clinical candidates from discovery into development
  • Experience with a variety of lead generation strategies including fragment-based and DEL screens
  • Proven ability to manage timelines and resources to drive projects toward key decision points
  • Track record of excellence supported by high impact, peer-reviewed publications and/or patents
  • Keen attention to detail with a strong sense of urgency and ability to work in a multi-disciplinary and team-focused environment
  • Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner
  • Drug discovery experience with additional modalities such as peptides and protein degradation
  • Experience in target validation campaigns
  • Drug discovery experience in the field of oncology, immuno-oncology or neuroscience
RECRUITING & STAFFING AGENCIES: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

Apply for this Job

* Required